化浊解毒方联合二甲双胍对2型糖尿病患者肠促胰素GLP-1的影响

Effect of removing turbidity and detoxication decoction combined with metformin on serum GLP-1 in patients with type 2 diabetes

关键词:  2型糖尿病  化浊解毒方  胰高血糖素样肽-1

Key words:  type 2 diabetes  removing turbidity and detoxication decoction  GLP-1

摘要:

[目的] 观察化浊解毒方联合二甲双胍对2型糖尿病(T2DM)患者血清胰高血糖素样肽-1(GLP-1)的影响。[方法] 筛选符合浊毒内蕴证型的T2DM患者,随机分为治疗组和对照组。治疗组在常规治疗基础上加服化浊解毒方,8周后评价患者临床证候的改善情况,检测血糖、胰岛素及GLP-1等相关指标。[结果] 治疗后,治疗组较对照组临床症状体征明显改善,血糖、糖化血红蛋白水平明显降低(P<0.05),GLP-1分泌显著增加(P<0.01),胰岛素水平无明显变化。[结论] 化浊解毒方联合二甲双胍能增加T2DM患者GLP-1分泌,从而增强其降糖疗效。

Abstract:

[Objective] To observe the effect of removing turbidity and detoxication decoction combined with metformin on serum GLP-1 in patients with type 2 diabetes. [Methods] Select patients with type 2 diabetes who belong to turbidity and detoxication syndrome, and divided into treatment group and control group randomly. The treatment group added removing turbidity and detoxication decoction on basis of conventional treatment. Evaluate the clinical symptoms and signs, also detect blood glucose, insulin, GLP-1 and other biochemical indexes after 8 weeks. [Results] The two groups showed no difference before treatment. Compared with the control group after treatment, the clinical symptoms and signs of treatment group significantly improved, blood glucose and glycated hemoglobin levels remarkably decreased(P<0.05), GLP-1 secretion increased obviously(P<0.01), but no differences in insulin level. [Conclusion] The blood sugar regulation effect of removing turbidity and detoxication decoction may be related to the promoting secretion of GLP-1.