“三焦膜系学说”指导治疗代谢综合征的实验研究

Experiments of treatment on metabolic syndrome by the guidance of “Sanjiao (triple energizer) membrane system theory”

关键词:  三焦膜系学说  代谢综合征  实验研究

Key words:  Sanjiao (triple energizer) membrane system theory  metabolic syndrome  experiment study

摘要:

[目的] 探讨三焦膜系学说的代表方丹蛇汤治疗代谢综合征的作用机制, 以揭示其在指导临床复杂疑难证治疗中的意义。[方法] 取 SPF 级Wistar雄性大鼠, 随机分为正常组、模型组、西药组、中药组。除正常组外, 各组大鼠均以高脂高盐饲料喂养。造模8周, 治疗组用药3周, 同时监测大鼠体质量、腹围、体长、空腹血糖、血压, 麻醉腹主动脉取血检测空腹胰岛素含量, 计算胰岛素抵抗指数(HOMA-IR).[结果] 中药组的血糖、血清胰岛素、胰岛素抵抗, 血压指标与模型组相比均显着降低(P<0.05),中药组与西药组比较无统计学差异。[结论] 丹蛇汤能对代谢综合征大鼠的糖代谢异常和高血压有治疗调节作用。

Abstract:

[Objective] Through the experiment research, we discussed the mechanism of the treatment of metabolic syndrome of the representative prescription-Dan snake decoction,which is guided by “Sanjiao (triple energizer) membrane system theory”, to reveal its significance in guiding the clinical treatment for complicated cases. [Methods] SPF, male Wistar rats were randomly divided into normal control group, model group, high fat and sugar high salt rosiglitazone, Dan snake decoction treatment group. In addition to the normal control group, each group of rats was fed with high fat and salt. Model Building 8 weeks, drug treatment group 3 weeks, at the same time monitoring in the rat body weight, abdominal girth, fasting blood glucose, blood pressure, anesthesia abdominal aorta take blood test fasting insulin levels, insulin resistance index (HOMA-IR). [Results] The blood glucose, serum insulin, insulin resistance, blood pressure index of Dan snake group compared with the model group were significantly lower (P<0.05), with rosiglitazone group was no significant difference. [Conclusion] Dan snake decoction can regulate on sugar metabolism and blood pressure of metabolic syndrome rats, and relieve symptoms from multiple angles.