健康大学生血清GC、ACTH、MT含量的四时观测及其与神经质、生活事件的关联性研究

Research on serum GC, ACTH, MT in four seasons and the correlation among neuroticism, life events and aforesaid 3 materies in healthy university undergraduates

关键词:  肝主疏泄  神经质  生活事件  糖皮质激素  促肾上腺皮质激素  褪黑素

Key words:  liver controlling dredging  neuroticism  life event  GC  ACTH  MT

摘要:

[目的] 调查健康大学生血清糖皮质激素(GC)、促肾上腺皮质激素(ACTH)、褪黑素(MT)的四时含量,研究人体生理状态下内分泌相关指标的四时表现特点及变化规律,分析上述指标与神经质及生活事件的关联性。[方法] 以308例北京、山东、山西3所中医药大学在校大学生为受试者。筛选阶段使用艾森克人格问卷简式量表中国版调查受试者人格;冬至节气前后7 d使用健康状况调查问卷及青少年生活事件自评量表调查受试者健康状况和生活事件。在4个时点即冬至、春分、夏至、秋分节气前后7 d对受试者进行抽血,统一检测血清GC、ACTH、MT含量。使用SPSS 20.0软件进行数据统计,分析受试者四时血清相关微观指标含量变化、不同神经质及生活事件受试者间的差异。[结果] 受试者四时血清GC、ACTH、MT含量差异有统计学意义。血清GC含量冬至最高、夏至最低。ACTH及MT含量夏至最高、春分最低。血清GC含量冬至节气高神经质高生活事件组受试者显著低于低神经质低生活事件组受试者,春分和秋分节气则与之相反。血清ACTH及MT含量夏至节气高神经质高生活事件组受试者显著高于低神经质低生活事件组受试者。两组受试者四时血清GC、ACTH、MT含量变化幅度和趋势不同。高神经质高生活事件组受试者郁闷、善太息等情绪及躯体不适出现频率更高,类似中医肝疏泄不足的表现。[结论] 健康人群血清GC、ACTH、MT含量有四时变化的规律。血清中GC、ACTH、MT的标含量与神经质、生活事件关系密切。依据中医理论进行分析,该差异可能与肝的疏泄功能相关。

Abstract:

[Objective] Survey the change law of the content of serum GC, ACTH and MT of healthy university undergraduates in four seasons, to investigate the features and change law of microcosmic indexes about endocrine secretion of human under physiological condition in four seasons, and to analyze the correlation among the materies mentioned above, neuroticism and life events. [Methods] This research was undertook from 308 subjects who were university undergraduates came from 3 universities of Chinese medicine in Beijing, Shandong and Shanxi. The personality of subjects was surveyed through EPQ-RSC on selection phase, and the healthy condition and life events of subjects were surveyed by using the questionnaire compiled by the research group and Adolescent Self-rating life events check list on 7 days pre and post the solar term of Dong zhi. Blood samples were collected on 7 days pre and post Dong Zhi, Chun Fen, Xia Zhi and Qiu Fen, and the content of serum GC, ACTH and MT were tested uniformly. The change of the contents of the microcosmic indexes in four seasons and the difference of the contents between 2 groups that were grouped by the score of neuroticism and life events were analyzed by the software of SPSS 20.0. [Results] The difference of contents of serum GC, ACTH and MT was significant among four seasons. The contents of serum GC was maximum in Dong Zhi, and it was lowest in Xia Zhi. The contents of serum ACTH and MT was maximum in Xia Zhi, and it was lowest in Chun Fen. The contents of serum GC of subjects with high score of neuroticism and life events is lower than the subjects with low score significantly in Dong Zhi, and it's higher than the subjects with low score significantly in Chun Fen and Qiu Fen. The contents of serum ACTH and MT of subjects with high score of neuroticism and life events was higher than the subjects with low score significantly in the solar term of Xia Zhi. The trend and change range of serum GC, ACTH and MT were different between two groups. More uncomfortable aesthema such as depression and preference for sighing were performed on subjects with high score of neuroticism and life events, and these aesthema seemed like the performances of the lack of liver controlling dredging according to traditional Chinese medicine. [Conclusion] The contents of serum GC, ACTH and MT of healthy people had change law in four seasons, and the contents of these indexes were correlated to neuroticism and life events closely. The difference might relate to whether liver controlling dredging displayed well according to traditional Chinese medicine.