| 摘要: |
| [目的] 研究氢化胡椒碱对光甘草定软膏体外透皮作用的影响。[方法] 通过改良Franz垂直扩散池考察光甘草定的透皮吸收性能,以高效液相色谱法测定光甘草定含量,以考察氢化胡椒碱、氮酮、冰片对光甘草定透皮吸收的影响。[结果] 不同促渗剂对光甘草定累积透过量顺序为0.04 %氢化胡椒碱组 >0.03 %氢化胡椒碱组 >0.02 %氢化胡椒碱组 >5 %氮酮组 >3 %氮酮组 >2 %冰片组>单体组,0.04 %氢化胡椒碱组的24 h的累积渗透量最大,为26.51 μg/cm2,其促渗速率的增渗倍数最大,较单体组提高了5.03倍。[结论] 不同的促渗剂对光甘草定均有促渗作用,并且0.04%氢化胡椒碱为透皮促渗剂对光甘草定体外透皮吸收效果最佳,可促进光甘草定快速有效的渗透。 |
| 关键词: 光甘草定 促渗剂 透皮吸收 氢化胡椒碱 |
| DOI：10.11656/j.issn.1672-1519.2016.03.13 |
| 分类号: |
| 基金项目:西青区科技型中小企业发展专项资金项目(XQKH2013-011);天津中医药大学第四届大学生科技创新基金项目(CXJJ2013ALL). |
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| Influence of Tetrahydropiperine on transdermal permeation of Glabridin in ointment |
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WANG Yan, YE Liu-qing, LIU Yuan-yuan, HAN Wan-ying, WANG Li-feng, SONg Chun-jing, ZHANG Yan-jun
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School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To investigate the effect of Tetrahydropiperine on transdermal of Glabridin in ointment. [Methods] Franz vertical diffusion cell was adopted to investigate transdermal performance of glabridin and observe the effect of Tetrahydropiperine(THP), azone, borneol on transdermal permeation of Glabridin. [Results] Effect of enhancers on Glabridin was ranked as follows: 0.04%THP > 0.03%THP > 0.02%THP > 5% azone > 3%azone > 2%borneol. When the content of THP was 0.04%, the cumulative permeation of Glabridin was the highest, up to 26.51 μg/cm2. The penetration rate amount with 0.04%THP was 5.03 times than which no permeation enhancer. [Conclusion] These different permeation enhancer have the effect of Glabridin, Glabridin can be permeated quickly and efficiently. |
| Key words: Glabridin penetration enhancers transdermal Tetrahydropiperine |
