扶正解毒祛瘀法方药择时给药防治非小细胞肺癌化疗所致骨髓抑制的临床研究

Clinical research on the traditional Chinese medicine of Fuzheng jiedu Quyu method to choose time for the prevention and treatment of bone marrow suppression caused by chemotherapy in non-small cell lung cancer

关键词:  扶正解毒祛瘀法  骨髓抑制  择时给药

Key words:  Fuzheng Jiedu Quyu method  bone marrow suppression  time-choosing administration

摘要:

[目的] 观察扶正解毒祛瘀法方药防治非小细胞肺癌化疗所致骨髓抑制的临床疗效。[方法] 采用完全随机化方法,将60例天津中医药大学第一附属医院非小细胞肺癌患者随机分成A组(提前7 d运用"扶正解毒祛瘀"加减方加化疗组)和B组(单纯化疗组),观察"扶正解毒祛瘀"方药提前7天给药对气虚毒瘀型非小细胞肺癌化疗的骨髓抑制发生率、免疫功能、细胞因子及生活质量的影响。[结果] 化疗2个周期结束后,在骨髓抑制发生率及骨髓抑制分级方面,治疗组降低骨髓抑制发生率,具有统计学意义(P<0.05);与对照组比较,治疗组白细胞、红细胞Ⅰ度、Ⅱ度人数减少,具有统计学意义(P<0.05)。在细胞因子方面,第1个化疗周期结束后,两组间细胞因子GM-CSF、IFN-γ比较具有统计学意义;第2个化疗周期结束后,两组间细胞因子IFN-γ比较具有统计学意义(P<0.05)。在生活质量方面,两组间患者KPS评分变化比较具有统计学意义(P<0.05)。[结论] 提前7 d运用"扶正解毒祛瘀"加减方加化疗与单纯化疗相比,在治疗非小细胞肺癌方面能够有效减轻化疗所致骨髓抑制的发生率,调节细胞因子浓度,一定程度上改善患者的生活质量。

Abstract:

[Objectives] To observe clinical efficacy of the prevention and treatment bone marrow suppression caused by chemotherapy by traditional Chinese medicine of Fuzheng Jiedu Quyu method. [Methods] Using completely randomized method, 60 cases of The First Affiliated Hospital of Tianjin Universi of Traditional Chinese Medicine non-small cell lung cancer patients were randomly divided into group A (7 days in advance using traditional Chinese medicine of Fuzheng Jiedu Quyu method joint chemotherapy group) and group B (pure chemotherapy group).We observe Chinese herbal 7 days in advance to bone marrow suppression in patients with non-small cell lung cancer chemotherapy the incidence of cytokines, immune function, and the influence of the quality of life. [Results] Chemotherapy after two cycles, the incidence of bone marrow suppression and bone marrow inhibition of classification, treatment group reduce the incidence of bone marrow suppression,it has statistical significance(P<0.05); compared with control group, treatment group decline in WBC and RBC 1, 2 degrees, it has statistical significance(P<0.05). After the first cycle of chemotherapy, in the aspect of cytokines, cell factor gm-csf, between the two groups of IFN-gamma is statistically significant. In terms of quality of life,patients KPS score comparison between the two groups have statistical significance (P<0.05). [Conclusion] Compared with the pure chemotherapy, using Chinese medicinec 7 days in advance combination chemotherapy can effectively reduce non-small cell lung cancer incidence of bone marrow suppression caused by chemotherapy, regulate cytokine concentrations, and to some extent improve the patient's quality of life.