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| 注射用血栓通对2型糖尿病GK大鼠视网膜病理结构的影响 |
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李芮琳, 孙作艳, 王金鑫, 王富江, 贾壮壮, 王少峡, 胡利民
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天津中医药大学中医药研究院, 天津市中药药理学重点实验室, 方剂学教育部重点实验室, 天津 300193
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| 摘要: |
| [目的]注射用血栓通（冻干）（XST）由三七主根为原料制成，本文探讨了其对GK大鼠糖尿病视网膜病理结构的影响，为治疗糖尿病视网膜并发症提供实验依据。[方法]GK 2型糖尿病大鼠随机分为模型组，100 mg/kg血栓通组，50 mg/kg血栓通组。血栓通组每天给予血栓通腹腔注射，另设Wistar对照组，对照组和模型病组给予等量的生理盐水，大鼠均于屏障环境中饲养治疗60 d。[结果]血栓通对糖尿病大鼠的体质量、血糖未见影响，能有效抑制糖尿病大鼠视网膜的收缩，改善各层的细胞结构。[结论]血栓通可改善GK2型糖尿病大鼠视网膜病理结构。 |
| 关键词: 注射用血栓通 糖尿病并发症 视网膜病变 |
| DOI：10.11656/j.issn.1672-1519.2018.02.14 |
| 分类号:R587.1 |
| 基金项目:国家重大新药创制（2012ZX09101201）；国家自然科学基金（81573644）；广西科学研究与技术开发计划（14125008-2-5）。 |
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| Effect of injection of Xueshuantong on retinal pathological structure of GK type 2 diabetic rats |
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LI Ruilin, SUN Zuoyan, WANG Jinxin, WANG Fujiang, JIA Zhuangzhuang, WANG Shaoxia, HU Limin
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Institute of Traditional Chinese Medicine Research of Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medicine Formula of Ministry of Education, Tianjin 300193, China
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| Abstract: |
| [Objective] Injection with Xueshuantong (freeze-dried) (XST) from the main root of Panax notoginseng made of raw materials, this paper was studied the effect of the pathological changes of diabetic retinopathy in Goto-Kakizaki (GK) rats, for the treatment of diabetic retinal complications to provide experimental basis.[Methods] GK type 2 diabetic rats were randomly divided into model group, 100 mg/kg XST group, 50 mg/kg XST group, intraperitoneal injection of XST per day, barrier treatment for 60 days. There was another Wistar control group. The control group and the model group were given the same amount of saline.[Results] The body weight and blood glucose of diabetic rats were not affected by thrombus, which could effectively inhibit the contraction of diabetic retina and improve the cell structure of each layer.[Conclusion] XST can improve the retinal pathological structure of GK type 2 diabetic rats. |
| Key words: injection of Xueshuantong diabetic complications retinopathy |
