银翘散调节呼吸道病毒感染相关性哮喘Th1/Th2细胞因子的临床观察

Clinical observation of Yinqiao powder for regulating respiratory virus associated asthma in Th1/Th2 cytokines

关键词:  呼吸道病毒感染相关性哮喘  银翘散  Th1/Th2  IFN-γ/IL-4

Key words:  respiratory virus associated asthma  Yinqiao powder  Th1/Th2  IFN-γ/IL-4

摘要:

[目的] 观察银翘散对呼吸道病毒感染相关性哮喘（RVA）的临床疗效及对Th1/Th2细胞因子的影响。[方法] 将68例RVA患者随机分为对照组32例，常规西药治疗；治疗组36例，在常规西药的基础上加用银翘散治疗。2组均治疗10 d。观察治疗前后患者的哮喘控制评分（ACT），肺功能[第1秒时间肺活量（FEV1）、一秒率（FEV1/FVC%）、呼气峰流速（PEF）]、中医证候疗效及Th1/Th2细胞因子[分泌性免疫球蛋白A（sIgA）、白介素-4（IL-4）、γ干扰素（IFN-γ）、IFN-γ/IL-4]的变化。[结果] 治疗后两组患者的ACT评分均较治疗前明显改善，且治疗组优于对照组（P<0.05）；治疗组对肺功能的改善优于对照组（P<0.05）。治疗组中医证候有效率为94.44%（34/36），对照组中医证候有效率为71.87%（23/32）。治疗后，治疗组sIgA水平高于对照组（P<0.05）。IFN-γ及IFN-γ/IL-4低于对照组（P<0.05），IL-4水平两组之间未见差异（P>0.05）。[结论] 银翘散联合常规西药治疗RVA的临床疗效优于单用常规西药治疗，可能与银翘散可调节患者Th1/Th2细胞因子，逆转因子间的失衡，进而减少气道炎症相关。

Abstract:

[Objective] To observe the clincal effect of Yinqiao powder on treating the respiratory virus associated Asthma(RVA) and Th1/Th2 cytokines. [Methods] The 68 RVA patients were randomly divided into control group (32 cases, conventional Western medicine treatment) and treatment group (36 cases, conventional Western medicine treatment+Yinqiao powder). Two groups were treated 10 days. In prior-treatment and post-treatment, the change of the related indexes were observed, including the asthma control test (ACT score), lung function(FEV1, FEV1/FVC%, PEF), curative effect of TCM and Th1/Th2 cytokines (sIgA, IL-4, IFN-γ, IFN-γ/IL-4). [Results] After treatment, two groups of ACT score was obviously improved, the treatment group was better than that of control group (P<0.05). On the lung function improvement, the treatment group was better than the control group(P<0.05). On TCM symptoms, the treatment group effective rate was 94.44% (34/36), the control of the effective rate was 71.87% (23/32). After treatment, the treatment group sIgA levels higher than the control group (P<0.05). IFN-4 and IFN-γ/IL-4 is lower than the control group (P<0.05), IL-4 levels not seen differences between two groups (P>0.05). [Conclusion] Yinqiao Powder combined with conventional Western medicine therapy RVA clinical curative effect is superior to the conventional Western medicine therapy, this may be related to Yinqiao Powder can regulate Th1/Th2 cytokines of patients, reverse the imbalance between factors, thereby reducing the airway inflammation.