消岩汤联合针灸疗法对化疗相关性疲乏影响的临床研究

Clinical study of Xiaoyan decoction combined with acupuncture and moxibustion therapy on fatigue related to chemotherapy

关键词:  化疗相关性疲乏  针灸疗法  癌性疲乏量表  生活质量

Key words:  chemotherapy related fatigue  acupuncture therapy  cancer fatigue scale  quality of life

摘要:

[目的]观察消岩汤联合针灸疗法对化疗相关性疲乏的影响。[方法]将80例患者按随机数字表法分为治疗组（40例）和对照组（40例）。两组患者根据病情需要均采用既定化疗方案化疗，治疗组从化疗第1天开始口服消岩汤（每日1剂，水煎服，300 mL，早晚分2次服用，连服3周）同时配合针灸治疗（每日1次，共3周）。对照组未给予其他干预措施。分别在化疗前、化疗第7天和化疗第21天采用癌性疲乏量表（CFS）、中医证候疗效评价及癌症治疗功能评估疲乏量表（FACT-F）比较两组患者在化疗前、化疗第7天、第21天疲乏、中医症状积分、生活质量的变化，并进行中医证候疗效比较。[结果]与本组化疗前比较，治疗组化疗第7天CFS在情感维度、躯体维度及总分较化疗前增加（P<0.05）；对照组化疗第7天、第21天CFS各维度及总分均较化疗前增加（P<0.05）。与本组化疗第7天比较，化疗第21天治疗组CFS各维度及总分均下降（P<0.05）；对照组情感维度及总分下降（P<0.05）。两组同期比较治疗组CFS各维度及总分均明显低于对照组（P<0.01）；中医症状积分治疗组总有效率为90.0%，明显优于对照组20.0%（P<0.01）；中医症状评分：与本组化疗前比较，治疗组化疗第7天患者的症状积分升高（P<0.05），第21天症状积分明显降低（P<0.01），对照组化疗第7天、第21天症状积分均升高（P<0.01）；与本组化疗第7天比较，两组化疗第21天治疗症状积分减低（P<0.01），两组同期（除治疗前）比较治疗组症状积分均低于对照组（P<0.01）；生活质量评分：与本组化疗前比较，治疗组化疗第7天情感状况及功能状况评分下降（P<0.05），第21天身体状况、情感状况、附加状况评分升高（P<0.05）；对照组化疗第7天各项指标评分均下降（P<0.05），化疗第21天身体状况、功能状况及附加状况评分降低（P<0.05）；与本组化疗第7天比较，治疗组与对照组各项指标评分均升高（P<0.05）；两组同期（除治疗前）对比治疗组各项指标评分均明显高于对照组（P<0.05）。[结论]消岩汤联合针灸疗法可有效改善患者的化疗相关性疲乏，提高生活质量。

Abstract:

[Objective] To observe the effect of Xiaoyan decoction combined with acupuncture on the fatigue related to chemotherapy.[Methods] The 80 patients were randomly divided into treatment group (40 cases) and control group (40 cases). The two groups were treated with chemotherapy regimen according to the needs of the disease. The treatment group started oral Xiaoyan Decoction (1 doses daily, water decoction, 300 mL, 2 times and 3 weeks) from the first day of chemotherapy and combined with acupuncture and moxibustion for 3 weeks (1 times a day for a total of 3 weeks). The control group did not give other intervention measures. Before chemotherapy, seventh days of chemotherapy and twenty-first days of chemotherapy, the cancer fatigue scale (cancer fatigue scale, CFS), TCM Syndrome Evaluation and cancer treatment function evaluation Fatigue Scale (FACT-F) were used to compare the changes of fatigue, TCM syndrome score and quality of life in two groups before chemotherapy, seventh days of chemotherapy, twenty-first days of chemotherapy, and the change of quality of life. The curative effect of medical syndrome was compared.[Results] Compared with this group before chemotherapy, the seventh days of CFS in the treatment group increased (P<0.05) in the emotional dimension, body dimension and total score than before chemotherapy (P<0.05), and the CFS dimensions and total scores of the control group increased (P<0.05) before chemotherapy, and the total score of CFS was higher than that before chemotherapy (P<0.05). Compared with the seventh days of chemotherapy in this group, all the dimensions and total scores of CFS in the twenty-first day chemotherapy group decreased (P<0.05), and the emotional dimension and total score of the control group decreased (P<0.05). The dimensions and total scores of CFS in the two groups were significantly lower than those in the control group (P<0.01), and the total effective rate of TCM syndrome integral treatment group was 90% significantly better than that of the control group (P<0.01). TCM syndrome score:compared with this group before chemotherapy, the syndrome score of the treatment group for seventh day patients increased (P<0.05), twenty-first (P<0.05), twenty-first The symptom score of day syndrome was significantly lower (P<0.01), and the symptom scores of seventh days and twenty-first days in the control group increased (P<0.01). Compared with the seventh day chemotherapy group, the symptom score of twenty-first days of chemotherapy was reduced (P<0.01). The symptom scores of the two groups were lower than those in the control group (P<0.01) during the same period (P<0.01); quality of life score:before chemotherapy in this group In comparison, the scores of emotional state and functional status in the treatment group decreased seventh days after chemotherapy (P<0.05). The score of physical condition, emotional state and additional condition increased (P<0.05) on the twenty-first day, and the scores of each index in the control group decreased (P<0.05), and the score of physical condition, function and additional condition of the twenty-first day chemotherapy decreased (P<0.05), and the scores of the treatment group and the control group were all higher than that in the seventh day chemotherapy group (P<0. 05); the 2 groups were significantly higher than those in the control group (P<0.05).[Conclusion] Xiaoyan decoction combined with acupuncture and moxibustion therapy can effectively improve the chemotherapy related fatigue and improve the quality of life in patients.