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肠道菌群失调影响抑郁情绪的研究进展
陈颖, 张丽萍, 宋瑞雯, 徐磊
天津中医药大学管理学院, 天津 300073
摘要:
抑郁情绪与肠道菌群的改变息息相关,近年来研究表明肠道菌群失调在抑郁情绪的发生发展中发挥关键作用。肠道菌群失调能够激活体内神经、内分泌免疫系统,导致机体的炎症等反应,通过胃肠神经系统,上传到中枢神经系统,引起抑郁情绪的发生。近年来研究发现,中医药可通过干预肠道菌群调节抑郁情绪,此外益生菌制剂亦有调节和恢复肠道菌群的作用,给予益生菌调节肠道菌群已成为治疗抑郁情绪的重要方法。
关键词:  肠道菌群  抑郁情绪  发病机制  研究进展
DOI:10.11656/j.issn.1672-1519.2018.08.22
分类号:R256.28
基金项目:国家自然科学基金面上项目(8167150502)。
Research progress on the influence of intestinal flora imbalance on depression
CHEN Ying, ZHANG Liping, SONG Ruiwen, XU Lei
School of Management, Tianjin University of Chinese Medicine, Tianjin 300073, China
Abstract:
Depression is closely related to the change of intestinal flora. In recent years, studies have shown that intestinal flora imbalance plays a key role in the development of depression. The intestinal flora imbalance can activate the nerve, endocrine and immune system in the body, and cause the inflammation of the body, and so on, through the gastrointestinal nervous system, uploaded to the central nervous system, causing the occurrence of depression. In recent years, the study found that Chinese medicine can adjust the depression through the intervention of intestinal flora, and probiotics are also in addition to regulate and restore the role of intestinal microflora, giving probiotics regulate intestinal flora has become an important method for the treatment of depression.
Key words:  intestinal flora  depression  pathogenesis  research progress
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