栗锦迁教授治疗胸痹用药规律研究

Regular drug usage of treatment in chest stuffiness and pains of Professor LI Jinqian

关键词:  胸痹  用药规律研究  中医传承辅助平台  栗锦迁

Key words:  chest obstruction  research in regulation of drug usage  TCMISS  LI Jinqian

摘要:

[目的]挖掘栗锦迁教授治疗胸痹的学术思想及其用药规律。[方法]应用中医传承辅助平台系统分析栗锦迁教授治疗胸痹用药的频次、四气、五味、归经、用药模式、关联性，并得到无监督的熵层次聚类分析新处方。[结果]通过分析栗锦迁教授治疗胸痹用药规律得到胸痹病机关键为心脉痹阻，病位在心，并涉及其余四脏，病机特点为本虚标实，虚实夹杂，虚者多见气虚、阳虚，实者多为气滞、寒凝、痰浊、血瘀，并多以相互搏结为患，常用治法为行气止痛、化痰除痹、活血化瘀、补气生血等，得到常用药对及11个新处方。[结论]应用中医传承辅助系统分析能进一步为研究胸痹常见证型的用药规律及新药研究提供有益的线索和启示，也为临床或基础研究提供了依据。

Abstract:

[Objective] Digging out the academic idea and regulation of drug usage of Professor LI Jinqian in treating chest obstruction.[Methods] Analyzing the frequency,four properties,five flavors,meridian distribution,pattern of prescription and relation by TCMISS,and getting new formula by cluster analysis.[Results] By analyzing the regulation of drug usage of Professor LI,the academic idea is achieved,which the key pathogenesis is blood stasis in heart vessel,and the pathogenesis characteristic wais deficient root with overdo superficial. It is common to find out qi-deficiency,yang-deficiency and qi-stagnation,cold coagulation,phlegm and blood stasis,which may be treated by promoting qi to relieve pain,removing phlegm to treat arthralgia,promoting blood circulation to remove blood stasis,tonifying qi and nourishing blood,which is presented in some drugs commonly used and 11 new formula.[Conclusion] It may get some experience of old famous traditional Chinese medicine doctors by using TCMISS,which is a good way to investigate drug usage of treatment in chest obstruction,in addition to research regulation of drug usage in common syndrome of chest obstruction,provide new evidence and inspiration of research in new drugs,and provide a basis for clinical or fundamental research.