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| 芪苈强心胶囊治疗慢性心力衰竭作用机制研究进展 |
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赵齐飞1,2, 李红蓉1,2, 尹玉洁2,3, 常丽萍3,4, 贾振华1,2,3
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1.河北医科大学研究生学院, 石家庄 050017;2.河北医科大学附属以岭医院, 国家中医药管理局中医络病学重点学科, 石家庄 050091;3.河北以岭医药研究院, 国家中医药管理局重点研究室, 石家庄 050035;4.石家庄以岭药业股份有限公司, 络病研究与创新中药国家重点实验室, 石家庄 050035
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| 摘要: |
| 慢性心力衰竭（慢性心衰）是心血管事件链中的关键环节，以中医脉络学说为指导研发的创新中药芪苈强心胶囊对慢性心衰具有良好疗效，研究表明该药能够增强心肌收缩力，利尿，抑制神经内分泌系统过度激活，抑制炎症反应、心肌纤维化、细胞凋亡和自噬，改善心肌能量代谢，促进血管新生，改善内皮功能，从而抑制心室重构，延缓慢性心衰进程。探讨芪苈强心胶囊治疗慢性心衰的作用及机制，有利于从多靶点、多通道发挥该药治疗作用，同时为心血管事件链中其他难治性疾病提供更广阔的治疗思路，对提高中医药治疗心血管疾病具有重大的理论与临床意义。 |
| 关键词: 慢性心力衰竭 脉络学说 芪苈强心胶囊 作用机制 |
| DOI：10.11656/j.issn.1672-1519.2019.04.01 |
| 分类号: |
| 基金项目:国家重点研发计划“中医药现代化研究”重点专项资助项目（2017YFC1700500）；河北省自然科学基金资助项目（H2018106043）。 |
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| Research progress on the effect and mechanism of Qili Qiangxin Capsule in treating chronic heart failure |
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ZHAO Qifei1,2, LI Hongrong1,2, YIN Yujie2,3, CHANG Liping3,4, JIA Zhenhua1,2,3
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1.Graduate School, Hebei Medical University, Shijiazhuang 050017, China;2.Affiliated Yiling Hospital of Hebei Medical University, Key Disciplines of State Administration of TCM for Collateral Disease, Shijiazhuang 050091, China;3.Hebei Yiling Pharmaceutical Research Institute, Key Laboratory of State Administration of TCM, Shijiazhuang 050035, China;4.Shijiazhuang Yiling Pharmaceutical Co., Ltd, National Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine, Shijiazhuang 050035, China
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| Abstract: |
| Chronic heart failure is a key part of cardiovascular continuum. Under the guidance of the theory of vessel-collateral doctrine,the present study proposes therapeutic benefits of Qili Qiangxin Capsules,an innovative Chinese medicine,on chronic heart failure. The studies show that multiple targets of the drug on chronic heart failure,including enhancing myocardial systole,promoting urine excretion,inhibiting excessive activation of the neuroendocrine system,preventing ventricular remodeling by inhibiting inflammatory response,myocardial fibrosis,apoptosis and autophagy,enhancing myocardial energy metabolism,promoting angiogenesis and improving endothelial function. To investigate the effect and mechanism of the drug is beneficial to the treatment of chronic heart failure through multiple targets or signaling pathways. Meanwhile,it provides new insights to further understand other refractory diseases in the cardiovascular continuum,and it also has an important theoretical and practical significance in enhancing prevention and therapeutic effect of traditional Chinese medicine for these diseases. |
| Key words: chronic heart failure vessel-collateral doctrine Qili Qiangxin Capsule the effect and mechanism |
