抗瘤增效方联合甘麦大枣汤加味对宫颈癌患者抑郁和睡眠指数及肿瘤指标的影响

Effect on the depression,sleep efficiency index and the tumor marker of patients with cervical cancer by treatment combined the Kangliu Zengxiao Decoction with Ganmai Dazao Decoction

关键词:  宫颈癌  中医药  抑郁  睡眠质量  肿瘤指标

Key words:  cervical cancer  traditional Chinese medicine  depression  sleep quality  tumor marker

摘要:

[目的]探讨抗瘤增效方联合甘麦大枣汤加味对宫颈癌术后或放化疗后抑郁患者睡眠质量和肿瘤相关指标的影响。[方法]将186例宫颈癌术后或放化疗后患者随机分为对照组（甘麦大枣汤加味）及治疗组（抗癌增效方联合甘麦大枣汤加味），比较两组患者干预3个月前后各项指标，包括汉密尔顿抑郁量表（HAMD）评分、匹兹堡睡眠质量指数（PSQI）评分以及相关肿瘤标志物（TM），评价抗瘤增效方联合甘麦大枣汤加味对宫颈癌术后或放化疗后患者的抑郁程度、睡眠质量及预后的疗效。[结果]干预3个月后，治疗组患者较对照组患者HAMD得分差异具有统计学意义（P<0.05）；对照组患者在入睡时间、睡眠时间、睡眠效率、睡眠障碍、安眠药物的使用以及PSQI总分等方面与干预前比较有所改善，差异有统计学意义（P<0.05）；治疗组干预后较干预前在入睡时间、睡眠时间、睡眠效率、睡眠障碍、安眠药物使用、日间功能以及PSQI总分等方面与干预前比较均有改善，差异有统计学意义（P<0.05）。治疗组患者在睡眠质量、安眠药物使用、日间功能方面明显优于对照组，差异有统计学意义（P<0.05）；与干预前相比，对照组患者的癌胚抗原（CEA）及鳞癌抗原（SCC）水平显著降低（P<0.05）。治疗组患者的CEA、糖类抗原199（CA199）、SCC水平均显著降低（P<0.05），且与对照组相比，治疗组CEA、糖类抗原125（CA125）、CA199、SCC均显著降低，差异具有统计学意义（P<0.05）。[结论]抗瘤增效方联合甘麦大枣汤能够全面改善宫颈癌术后或化放疗后患者抑郁程度及睡眠质量，降低患者肿瘤指标，改善患者的预后。

Abstract:

[Objective] To investigate the effect on the depression,sleep efficiency index and the tumor marker of the postoperative patients or after irradiation and chemotherapy with cervical cancer by treatment combined the Kangliu Zengxiao Decoction with Ganmai Dazao Decoction.[Methods] The 186 postoperative patients or after irradiation and chemotherapy with cervical cancer were randomly divided into two groups:the Control Group (Ganmai Dazao Decoction) and the Treatment group (Kangliu Zengxiao Decoction with Ganmai Dazao Decoction). The indexes of the two groups were compared before and after intervention for three months. Hamilton Depression Scale (HAMD) score,Pittsburgh Sleep Quality Index (PSQI) score,and related tumor markers (TM),the effect of Kangliu Zengxiao Decoction with Ganmai Dazao Decoction was evaluated.[Results] The difference in HAMD scores between the treatment and the control groups was statistically significant after treatment for 3 months (P<0.05). The control group had better improvement in time for falling asleep,sleep time,sleep efficiency,sleep disorder,use of sleeping pills,and total PSQI scores before intervention. The difference was statistically significant (P<0.05); Compared with the pre-intervention,the differences in time for falling asleep,sleep time,sleep efficiency,sleep disorder,use of the sleeping pills,day function and PSQI scores were improved,and the difference was statistically significant (P<0.05). Patients in the treatment group were significantly better than the control group in terms of sleep quality,the use of hypnotic drugs,and day function,with statistically significant differences (P<0.05). Compared with ore-intervention,the levels of the CEA and SCC in the control group were significantly lower than before (P<0.05). For the treatment group,the levels of CEA,CA199,and SCC were significantly lower (P<0.05),the levels of the CEA,CA125,CA199,and SCC were all significantly lower in the treatment group than in the control group,the difference was statistically significant (P<0.05).[Conclusions] The depression level and sleep quality of the postoperative patients or after irradiation and chemotherapy with cervical cancer can comprehensively be improved by the treatment combined the Kangliu Zengxiao Decoction with Ganmai Dazao Decoction. The levels of the tumor marker were decreased,the outcome of the patients were improved.