中医药调整脑内微环境改善阿尔兹海默病引发认知损伤作用效果及生物学机制研究进展

Effect of traditional Chinese medicine on the brain microenvironment to improve cognitive effects of Alzheimer’s disease and its biological mechanism

关键词:  阿尔茨海默病  脑内微环境  脑淋巴引流  硬脑膜淋巴管  中医药

Key words:  Alzheimer's disease  brain microenvironment  cerebral lymphatic drainage  dual lymphatics  traditional Chinese medicine

摘要:

阿尔茨海默病病因复杂，目前其发病病因、病机尚未得到完全阐明，尚无特别有效的治疗药物。西医学认为该病的发生可能与遗传、自身免疫、环境、衰老等因素导致的脑内微环境异常有关，是其进行性加重的重要原因，脑内物质淋巴引流是改善脑内微环境防治阿尔茨海默病的重要手段。随着传统中医“毒损脑络”病机及西医学对阿尔茨海默病发病过程中脑内微环境、淋巴引流等组织形态学以及功能学认识的不断深化，系统阐明中医药调整脑内微环境改善阿尔兹海默病引发认知损伤作用效果及生物学机制已成为可能，并且对进一步指导临床应用具有重要意义。

Abstract:

The etiology of Alzheimer's disease is complex. At present,the etiology and pathogenesis of Alzheimer's disease have not been fully elucidated,and there are no very effective therapeutic drugs. Modern medicine believes that the occurrence of this disease may be related to abnormalities in the microenvironment of the brain caused by factors such as genetics,autoimmunity,environment,and aging whichmay also lead to the progressive exacerbation. Intracranial lymphatic drainage is an effective method to improvethe microenvironments of Alzheimer's disease.In view of the pathogenesis of "toxic damage to the brain collaterals" in traditional Chinese medicine and the understanding of histomorphology and functional understanding of the brain microenvironment and lymphatic drainage during the onset of Alzheimer's diseasein modern medicine,wesummarize and clarify that traditional Chinese medicine adjusts the brain microenvironment to improve the effects and biological mechanism of cognitive impairment induced by Alzheimer's disease,which is of great significance to further guide clinical application.