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| 通心络胶囊治疗心肌梗死后心力衰竭的研究进展 |
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秘红英1, 宋红霞1, 李雅文2, 张薇3, 孙永辉1, 谷会会1, 张凤虹1, 王淑敏1, 崔静1, 贾萌萌1, 贾振华1,2
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1.河北以岭医院, 石家庄 050091;2.河北中医学院, 石家庄 050091;3.石家庄市妇幼保健院, 石家庄 050091
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| 摘要: |
| 心肌梗死后心力衰竭（简称心梗后心衰）作为心肌梗死患者最常见、最危险的并发症，给人们的健康和生活带来了极大的威胁。以吴以岭教授创立的“脉络学说”为理论指导研制出的通心络胶囊作为通络代表方药，经研究证实，可改善心梗后心衰的心功能、增加心排血量，降低血清炎症因子水平，减少心肌再灌注损伤及无复流现象，减慢心室重构的进程，延缓心梗后心衰的进展，显著降低心梗后心衰的病死率，改善患者预后。 |
| 关键词: 心肌梗死后心力衰竭 脉络学说 通心络胶囊 再灌注损伤 心肌无复流 |
| DOI：10.11656/j.issn.1672-1519.2020.09.26 |
| 分类号:R24 |
| 基金项目:国家重点研发计划“中医药现代化研究”重点专项资助项目（2017YFC1700500）；河北省中医药管理局科研计划项目（2020242）；石家庄市科学技术研究与发展计划项目（191200913）；河北省自然科学基金资助项目（H2018106043）。 |
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| Research progress of Tongxinluo Capsule in the treatment of heart failure after myocardial infarction |
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MI Hongying1, SONG Hongxia1, LI Yawen2, ZHANG Wei3, SUN Yonghui1, GU Huihui1, ZHANG Fenghong1, WANG Shumin1, CUI Jing1, JIA Mengmeng1, JIA Zhenhua1,2
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1.Hebei Yiling Hospital, Shijiazhuang 050091, China;2.Hebei University of Chinese Medicine, Shijiazhuang 050091, China;3.Shijiazhuang Maternal and Child Health Hospital, Shijiazhuang 050091, China
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| Abstract: |
| Heart failure after myocardial infarction (post infarction heart failure) as the most common and dangerous complication of patients with myocardial infarction,has brought great threat to people's health and life. Tongxinluo Capsule,which was developed under the guidance of “vessel-collateral theory” founded by Professor WU Yiling,is a representative prescription for dredging collaterals. It has been proved by research that it can improve heart function,increase cardiac output,reduce serum inflammatory factors level,reduce myocardial reperfusion injury and no reflow phenomenon,slow down the process of ventricular remodeling,delay the progress of post infarction heart failure,significantly reduce the mortality of heart failure after myocardial infarction and improve the prognosis of patients. |
| Key words: heart failure after myocardial infarction vessel-collateral theory Tongxinluo Capsule myocardial reperfusion injury myocardial no reflow |
