乙型肝炎病毒相关性肾炎中西医结合研究述评

Research review of integrated traditional Chinese and Western medicine for hepatitis B virus associated glomerulonephritis

关键词:  乙型肝炎病毒相关性肾炎  肾纤维化  中西医结合

Key words:  hepatitis B virus associated glomerulonephritis  renal fibrosis  integrated traditional Chinese and Western medicine

摘要:

乙型肝炎病毒相关性肾炎是感染乙型肝炎病毒后引起免疫复合物沉积在肾脏导致的疾病，是中国常见的继发性肾小球疾病之一，多见于儿童，预后较好。部分发展至晚期会引起肾间质纤维化。由于目前尚未创建可靠的动物模型、传染性大，导致对于乙型肝炎病毒相关性肾炎的研究存在一定困难。分子生物学主要从细胞转染来研究，研究认为乙型肝炎病毒X蛋白（HBx）与肾小管上皮细胞的凋亡有关。目前研究瓶颈在于缺乏实验研究，临床无统一治疗方案，缺乏大范围、多中心研究。预防乙型肝炎病毒感染最有效的方法是接种乙型肝炎疫苗。目前中西医结合治疗乙型肝炎病毒相关性肾炎取得了一定临床效果，中医从辨证论治、分期论治、中医专方专药等方面治疗乙型肝炎病毒相关性肾炎及防治肾纤维化取得了一定的临床疗效，西医治疗兼顾乙型肝炎及肾小球肾炎两方面。文章将从研究瓶颈、实验研究进展、研究方向、展望等4个部分来论述乙型肝炎病毒相关性肾炎，以期为临床研究乙型肝炎病毒相关性肾炎提供参考。

Abstract:

Hepatitis B virus associated glomerulonephritis is a disease caused by the deposition of immune complexes in the kidneys after infection with hepatitis B virus. It is one of the common secondary glomerular diseases in China. It is more common in children and has a better prognosis. Partial development to advanced stages can cause renal interstitial fibrosis. At present,there is no reliable animal model and it is highly contagious,which leads to some difficulties in the research of hepatitis B virus associated glomerulonephritis. Molecular biology mainly focuses on cell transfection,and research suggests that hepatitis B virus X protein (HBx) is related to apoptosis of renal tubular epithelial cells. Current research bottlenecks are the lack of experimental research,the lack of a unified clinical treatment plan,and the lack of large-scale,multi-center research. The most effective way to prevent hepatitis B virus infection is to inoculate hepatitis B vaccine. At present,the treatment of hepatitis B virus associated glomerulonephritis with integrated traditional Chinese and Western medicine has achieved certain clinical effects. Traditional Chinese medicine has achieved certain clinical effects in treating hepatitis B virus associated glomerulonephritis and preventing and treating renal fibrosis from the aspects of syndrome differentiation,treatment by stages,and special prescriptions of traditional Chinese medicine. This article will discuss hepatitis B virus associated glomerulonephritis from four parts:research bottleneck,experimental research progress,research direction and prospect,in order to provide reference for clinical treatment of hepatitis B virus associated glomerulonephritis.