运用中西医结合单元疗法治疗老年急性白血病临床疗效观察

Observation on clinical efficacy of senile acute leukemia treated by integrated traditional Chinese and Western medicine unit therapy

关键词:  中西医结合  单元疗法  老年急性髓系白血病  缓解率  不良反应

Key words:  combination of Chinese and Western medicine  unit therapy  elderly patients with acute myeloid leukemia  remission rate  adverse reaction

摘要:

[目的] 观察中西医结合单元疗法对治疗老年急性髓系白血病的临床缓解率及不良反应的影响。[方法] 将54例老年白血病患者分为两组，对照组26例，单用西药化疗治疗，治疗组28例，以单元疗法为指导，在对照组化疗基础上加用中药汤剂。观察1个化疗周期后两组的临床缓解率，微小残留白血病值，血常规、肝功能、肾功能、心脏指标及输血量。[结果] 治疗组总有效率比对照组高（P<0.05），微小残留白血病值比对照组低（P<0.05）；治疗组在肝功能、肾功能、乳酸脱氢酶及输血小板数量方面均有改善，具有统计学意义。[结论] 中西医结合单元疗法能够增加化疗治疗效果，提高临床缓解率，减轻化疗不良反应，提高化疗耐受性，减少化疗相关病死率。

Abstract:

[Objective] To observe the effect of integrated traditional Chinese and Western medicine unit therapy on clinical remission rate and adverse reactions of senile acute myeloid leukemia. [Methods] The 54 cases of elderly leukemia patients were divided into two groups,26 cases in control group,treated with Western medicine only,and 28 cases in treatment group,guided by integrated traditional Chinese and Western Medicine unit therapy,treated with traditional Chinese medicine decoction on the basis of chemotherapy. The remission rate,MRD,blood routine index,liver function index,kidney function index,cardiac index,and blood transfusion amount after one chemotherapy cycle were observed. [Results] The total effective rate of the treatment group was higher than that of the control group (P<0.05),the MRD value was lower than that of the control group (P<0.05). There was statistically obvious improvement in liver function,renal function,LDH and platelet transfusion were improved in treatment group. [Conclusion] Integrated traditional Chinese and Western medicine unit therapy can significantly increase the therapeutic effect of chemotherapy,improve the remission rate,reduce the adverse reactions of chemotherapy,improve the tolerance of chemotherapy,and reduce the death rate related to chemotherapy.