益气活血解毒方联合化疗对晚期胰腺癌患者的影响

Effects of Yiqi Huoxue Jiedu Prescription combined with chemotherapy on advanced pancreatic cancer patients

关键词:  益气活血解毒方  晚期胰腺癌  肿瘤标志物  免疫球蛋白  半乳糖凝集素-9

Key words:  Yiqi Huoxue Jiedu Prescription  advanced pancreatic cancer  tumor marker  immunoglobulin  galactose lectin-9

摘要:

[目的] 探究益气活血解毒方联合化疗对晚期胰腺癌的临床效果，分析其对患者血清癌胚抗原（CEA）、胰癌胚抗原（POA）、胰腺癌相关抗原（PCAA）、免疫球蛋白以及半乳糖凝集素-9（Gal-9）水平的影响。[方法] 选取2015年2月—2017年5月在本院接受治疗的94例晚期胰腺癌患者，将其随机分为观察组与对照组，各47例。对照组接受化疗治疗，观察组在此基础上联用益气活血解毒方进行治疗，对两组患者的治疗效果进行分析比较。[结果] 观察组的近期疗效明显优于对照组（P<0.05）。治疗前，两组患者血清CEA、POA、PCAA比较无统计学差异（P>0.05），治疗后，观察组血清CEA、POA、PCAA水平均明显低于对照组（P<0.05）；观察组各神经浸润相关分子水平均明显低于对照组（P<0.01）；观察组细胞因子水平均明显高于对照组（P<0.01）；观察组免疫球蛋白水平均明显高于对照组，Gal-9水平明显低于对照组（P<0.01）。两组患者出现的不良反应类型包括：血小板减少、白细胞减少、上消化道反应及腹泻等，其中观察组上消化道反应及腹泻发生率明显低于对照组（P<0.05），两组患者血小板减少及白细胞减少发生率比较无统计学差异（P>0.05）。[结论] 益气活血解毒方联合化疗可以显著提高晚期胰腺癌患者的治疗效果，降低神经浸润相关分子水平，减少毒副反应，增强机体的免疫应答。

Abstract:

[Objective] To explore the clinical effect of Yiqi Huoxue Jiedu Prescription combined with chemotherapy in the treatment of advanced pancreatic cancer,and analyze its effects on the serum CEA,POA,PCAA,immunoglobulin and galactose lectin-9 levels.[Methods] The 94 patients with advanced pancreatic cancer who were treated in our hospital from February 2015 to May 2017 were selected and randomly divided into observation group and control group,with 47 cases each. The control group received chemotherapy,and the observation group was treated with Yiqi Huoxue Jiedu Prescription on the basis,and the therapeutic effects of the two groups were analyzed and compared.[Results] The remission rates of objective disease in the observation group and,and the therapeutic effect in observation group was significantly better than that in control group (P<0.05). After treatment,the serum CEA,POA and PCAA levels in the observation group were significantly lower than those in control group(P<0.05). After treatment,the levels of p75,TrkA,TrkB,NGF and BDNF in the observation group were significantly lower than those in the control group(P<0.01). The levels of cytokines TNF-α,IFN-γ, IL-2 and IL-12 in the observation group were significantly higher than those in the control group (P<0.01). The level of immunoglobulin in observation group was significantly higher than that in control group,and the level of Gal-9 was significantly lower than that in the control group(P<0.01). The adverse reactions in two groups included thrombocytopenia,leukopenia,upper gastrointestinal reaction,diarrhea,etc. The incidence of upper gastrointestinal reaction and diarrhea in observation group was significantly lower than that in control group(P<0.05),and there was no significant difference in the incidence of thrombocytopenia and leukopenia between two groups (P>0.05).[Conclusion] The combination of Yiqi Huoxue Jiedu Prescription and chemotherapy can significantly improve the therapeutic effect of advanced pancreatic cancer patients,reduce the level of relevant molecules in nerve infiltration,reduce toxic and side effects,and enhance the immune response of the body.