消岩颗粒联合低分子肝素钠改善气虚血瘀型晚期非小细胞肺癌患者血液高凝状态的临床观察

Clinical observation of Xiaoyan Particle combined with low-molecular-weight heparin sodium on the hyper-coagulable state of qi deficiency and blood stasis type in advanced non-small-cell lung cancer patients

关键词:  非小细胞肺癌  高凝状态  气虚血瘀型  中药  消岩颗粒

Key words:  non-small cell lung cancer  hyper-coagulable state  qi deficiency and blood stasis type  Chinese medicine  Xiaoyan Particle

摘要:

[目的] 观察消岩颗粒联合低分子肝素钠对气虚血瘀型晚期非小细胞肺癌患者血液高凝状态的临床疗效。[方法] 收集2017年7月-2019年9月60例符合纳入标准的晚期气虚血瘀型非小细胞肺癌合并血液高凝状态患者，采取统计学随机分组方法分为治疗组与对照组，治疗组（消岩颗粒联合低分子肝素钠治疗）30例，对照组（低分子肝素钠治疗）30例。两组患者均采用抗凝治疗，即皮下注射低分子肝素钠5 000 U（每日1次），治疗组加用天津中医药大学第一附属医院院内制剂消岩颗粒（口服，每日两次），连续服用14 d，观察周期21 d为1个疗程，共观察2个疗程。观察两组治疗周期前后血清学D-二聚体定量、凝血指标[凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）]、血小板（PLT）数量、中性粒-淋巴细胞比值（NLR）、中医症状积分、生活质量评分，以及血常规、肝肾功能等安全性指标，所得数据采用SPSS 19.0统计软件进行统计学分析并记录。[结果] 针对气虚血瘀型晚期非小细胞肺癌合并血液高凝状态患者，消岩颗粒联合低分子肝素钠可降低其血清学D-二聚体定量、NLR，改善乏力、肢体麻木症状，提高生活质量。[结论] 消岩颗粒联合低分子肝素钠可显著改善气虚血瘀型晚期非小细胞肺癌合并血液高凝状态患者的血液高凝状态，提高其生活质量，安全性较好。

Abstract:

[Objective] To observe the curative effect of Xiaoyan Particles to the hyper-coagulable state of qi deficiency and blood stasis type advanced non-small-cell lung cancer patients.[Methods] Based on the inclusion criterion, 60 advanced non-small-cell lung cancer patients with hyper-coagulable state of qi deficiency and blood stasis type were collected that accepted treatment in oncology department of First Teaching Hospital of Tianjin University of traditional Chinese medicine during June 2017 to September 2019, and statistically randomly divided into treatment group and control group, each group contained 30 cases. Each group were both hypodermic injected low-molecular-weight Heparin Sodium 5 000 U once a day for continuous 14 days, and the treatment group was given Xiaoyan Particles twice a day additionally for continuous 14 days, and treatment cycle contained 21 days and 2 cycles at all. D-dimer and coagulation index(prothrombin time, activated partial thromboplastin time), platelet count, neutrophil-lymphocyte ratio(NLR), Chinese medicine four diagnostic scores, life quality, safety indicators such as blood routine, liver and kidney function were detected, meanwhile the SPSS 19.0 statistical software was used to record and analyse.[Results] As to the hyper-coagulable state of qi deficiency and blood stasis type advanced non-small-cell lung cancer patients, Xiaoyan Particles, combined with low-molecular-weight heparin sodium canreduce the level of D-dimer, NLR, alleviate symptoms of weakness and numbness, and enhance the quality of life.[Conclusion] Xiaoyan Particles combined with low-molecular-weight heparin sodium can ameliorate the hyper-coagulable state of qi deficiency and blood stasis type advanced non-small-cell lung cancer patients, and improve the quality of life, with good safety.