基于p38MAPK信号通路探讨中医药治疗心肌缺血再灌注损伤的研究进展

Discussion on the research progress of traditional Chinese medicine for myocardial ischemia-reperfusion injury based on p38MAPK signaling

关键词:  心肌缺血再灌注损伤  p38MAPK  中医药

Key words:  myocardial ischemia-reperfusion injury  p38MAPK  traditional Chinese medicine

摘要:

心肌缺血性疾病是导致人类死亡的重要因素，随着经皮冠状动脉介入、搭桥术及溶栓术等介入治疗手段的应用发展，使心肌缺血后能够重新得到血液供应，但是随之而来的再灌注损伤愈加受到临床工作者的重视。p38MAPK信号通路作为丝裂原活化蛋白激酶超家族的重要成员之一，可通过传递细胞内信号参与调控多种胞内应答反应，如炎症反应，细胞应激、凋亡等，在心肌缺血再灌注损伤（MIRI）中发挥重要作用。近年来，中医药以其独特的优势在治疗MIRI方面取得较大进展，日益受到医学界的广泛关注。本文将以p38MAPK信号通路作为切入点，探讨中医药治疗MIRI的作用机制。

Abstract:

Myocardial ischemic disease is an important factor leading to human death. With the application and development of interventional treatments such as percutaneous coronary intervention,bypass surgery,and thrombolysis,blood supply can be restored after myocardial ischemia. The reperfusion injury that comes has received more and more attention from clinicians. As one of the important members of the mitogen-activated protein kinase superfamily,the p38MAPK signaling pathway can participate in the regulation of a variety of intracellular responses by transmitting intracellular signals,such as inflammation,cellular stress,and apoptosis. This signaling pathway plays an important role in perfusion injury(MIRI). In recent years,traditional Chinese medicine has made great progress in the treatment of MIRI with its unique advantages,and has received widespread attention from the medical community. In order to further study the mechanism of action of Chinese medicine in the treatment of MIRI,this article will use the p38MAPK signaling pathway as an entry point.