| 摘要: |
| [目的]探讨加味芍药汤联合美沙拉秦治疗湿热下注型溃疡性结肠炎（UC）的临床疗效。[方法]选取2020年11月—2022年1月就诊于河北省中医院的UC患者64例作为研究对象，并通过随机数字表法将研究对象随机分成观察组32例和对照组32例。观察组给予加味芍药汤联合美沙拉秦肠溶片（莎尔福）口服治疗，对照组给予美沙拉秦肠溶片口服治疗，两组患者均需要进行为期8周的治疗，对比两组治疗前后的中医证候积分（TCMPS）评分、血清炎症因子水平、肠镜检查评分各项指标的变化及临床疗效、不良反应。[结果]两组患者治疗后的血清C反应蛋白（CRP）、白介素（IL）-13、肿瘤坏死因子（TNF）-α含量均较治疗前降低，且观察组的下降程度相比对照组明显，差异具有统计学意义（P＜0.05）；两组TCMPS评分、肠镜检查评分均较治疗前降低，且观察组治疗后的评分比对照组下降程度明显，差异具有统计学意义（P＜0.05）；观察组的总有效率以及治疗效果均优于对照组，差异具有统计学意义（P＜0.05）。[结论]对UC患者来说，采用加味芍药汤联合美沙拉秦治疗可以获得较好的疗效，不仅能够帮助UC患者大幅度缓解临床症状而且能够减轻机体自身的炎性反应，具有良好的治疗效果，且有较好的安全性。 |
| 关键词: 溃疡性结肠炎 炎症因子 美沙拉秦 加味芍药汤 |
| DOI：10.11656/j.issn.1672-1519.2023.02.06 |
| 分类号:R574.62 |
| 基金项目: |
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| Clinical study of Modified Shaoyao Decoction combine with mesalazine in the treatment of damp-heat ulcerative colitis |
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ZHANG Xiaoyu, CHEN Aixia, LIU Xiaoyi
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The Second Departmet of Proctology, The First Affiliated Hospital of Hebei University of Traditional Chinese Medicine, Shijiazhuang 050000, China
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| Abstract: |
| [Objective] To survey the clinical effect of Modified Shaoyao Decoction combine with mesalazine in the treatment of damp-heat ulcerative colitis.[Method] The 64 patients with ulcerative colitis treated in Hebei Hospital of Traditional Chinese Medicine from November 2020 to January 2022 were selected. All the patients were randomized into two groups,32 cases in each group,the experiment group was treated by Modified Shaoyao Decoction combine with mesalazine,and the control group adopted mesalazine,to compare TCMPS score,serum inflammatory factor,colonoscopy score,clinical efficacy and adverse reactions between both groups after eight weeks of treatment.[Results] After treatment,two groups serum inflammatory factor CRP,IL-13,TNF-α were decreased. The decrease degree of experiment group was more obvious than control group(P＜0.05). Both of 2 groups TCMPS score,colonoscopy score were decreased. The decrease degree of experiment group was more obvious than control group(P＜0.05). The effective rate and clinical efficacy of experiment group were significantly higher than control group(P＜0.05).[Conclusion] Modified Shaoyao Decoction combine with mesalazine to treat ulcerative colitis have a good effect,it can effectively improve the clinical symptoms of ulcerative colitis patients,reduce inflammatory reaction,curative effect is definite,and safety is good. |
| Key words: ulcerative colitis inflammatory cytokine mesalazine Modified Shaoyao Decoction |
