基于图论理论探究针刺对无先兆偏头痛患者脑功能网络的研究

Research on brain function network of patients with migraine without aura by acupuncture based on graph theory

关键词:  无先兆偏头痛|针刺|图论理论|脑功能网络|功能磁共振

Key words:  migraine without aura|acupuncture|graph theory|brain functional network|fMRI

摘要:

[目的] 观察无先兆偏头痛患者脑功能网络的拓扑属性改变，探究针刺治疗无先兆偏头痛的中枢效应机制。[方法] 纳入20例无先兆偏头痛患者和20例匹配的健康受试者，患者在针刺疗程前后分别进行1次功能磁共振扫描，采用基于全脑体素水平的度中心度（DC）分析方法和基于图论理论的大尺度脑功能网络分析方法，对比无先兆偏头痛患者与健康受试者、患者针刺前后拓扑指标的变化特点。[结果] 与健康受试者相比，无先兆偏头痛患者DC降低的脑区有左侧辅助运动区、边缘叶、额回内侧面、左侧扣带回中部，无DC升高脑区，且无先兆偏头痛患者的聚类系数和局部效率明显下降，最短路径、小世界指数、全局效率呈下降趋势。与针刺前相比，无先兆偏头痛患者针刺后的聚类系数、局部效率、小世界指数、全局效率有升高趋势。[结论] 针刺治疗能改善无先兆偏头痛患者下降的聚类系数和局部效率等拓扑指标。

Abstract:

[Objective] To observe the changes of brain function network in patients with migraine without aura and compare them with normal people,and to explore the central effect mechanism of acupuncture in the treatment of migraine without aura.[Methods] Twenty patients with migraine without aura and twenty healthy subjects who met the inclusion criteria were selected. The patients underwent fMRI scans before and after acupuncture treatment,and degree centrality based on the whole brain voxel level was used,and a large-scale brain function network analysis method based on graph theory was used to compare the changed characteristics of topological indexes before and after acupuncture in patients and healthy people.[Results] Compared with healthy subjects,the brain regions with reduced DC in migraine patients without aura were left supplementary motor area,limbic lobe,medial frontal gyrus,left middle cingulate gyrus,no DC increased brain regions,and the clustering coefficient and local efficiency of patients with migraine without aura decreased significantly,and the shortest path,small-world index,and global efficiency decreased. Compared with before acupuncture,patients with migraine without aura had higher clustering coefficient,local efficiency,small-world index,and global efficiency.[Conclusion] Acupuncture treatment can improve topological indicators such as clustering coefficient and local efficiency in patients with migraine without aura.