针刺治疗多囊卵巢综合征机制研究进展

Research progress on the mechanism of acupuncture in the treatment of polycystic ovary syndrome

关键词:  多囊卵巢综合征  针刺  机制  神经内分泌  炎症  子宫容受性

Key words:  polycystic ovary syndrome  acupuncture  mechanism  neuroendocrine  inflammation  uterine receptivity

摘要:

针刺治疗多囊卵巢综合征（PCOS）疗效肯定，且具有自身独特优势。文章通过检索近年针刺治疗PCOS的基础研究文献，总结其主要作用机制涉及以下几个方面：1）调节下丘脑-垂体-卵巢轴、交感-迷走神经与β-内啡肽、糖脂代谢改善神经-内分泌紊乱、调控神经递质和激素水平缓解负面情绪。2）调控炎症反应的信号通路及炎症相关因子抑制炎症状态。3）调节肠道菌群纠正代谢紊乱和控制全身炎症。4）调节“下丘脑-垂体-卵巢-子宫”生殖轴和卵巢功能，提高子宫内膜容受性。从以上多角度阐述针灸治疗多囊卵巢综合征的机制，旨在为临床上针刺干预PCOS提供理论依据。

Abstract:

Acupuncture is effective in the treatment of polycystic ovary syndrome (PCOS) and has its own unique advantages. This article retrieves the basic research literature of acupuncture in the treatment of PCOS in recent years,and summarizes the main mechanisms of action involving the following aspects:1) regulating the hypothalamic-pituitary-ovarian axis,sympathetic-vagus nerve and β-endorphins,glycolipid metabolism to improve neuro-endocrine disorders,regulates neurotransmitter and hormone levels to relieve negative emotions;2) signal pathways that regulate inflammatory responses and inflammation-related factors inhibit inflammatory states were regulated;3) regulate the intestinal flora to correct metabolic disorders and control systemic inflammation;4) regulate the reproductive axis and ovarian function of "hypothalamic-pituitary-ovarian-uterus" and improve endometrial receptivity. The mechanism of acupuncture in the treatment of polycystic ovary syndrome is elaborated from the above perspectives,aiming to provide a theoretical basis for the clinical intervention of acupuncture in PCOS.