通窍鼻炎颗粒与抗组胺药联合治疗对变应性鼻炎患者临床症状及生活质量的影响

Effects of Tongqiao Biyan Granules combined with antihistamine in the treatment of allergic rhinitis patients and its influence on clinical symptoms and quality of life

关键词:  盐酸氮卓斯汀  通窍鼻炎颗粒  变应性鼻炎  生活质量

Key words:  aztrostine hydrochloride  Tongqiao Biyan Granules  allergic rhinitis  quality of life

摘要:

[目的]分析通窍鼻炎颗粒与抗组胺药联合治疗对变应性鼻炎(AR)患者临床症状及生活质量的影响。[方法]纳入2019年4月—2021年5月在海南医学院第二附属医院收治的AR患者126例,按随机方法分组,每组各63例。对照组采用盐酸氮卓斯汀治疗,观察组在对照组的基础上加用通窍鼻炎颗粒。比较两组患者临床症状、鼻-结膜炎相关生活质量问卷(RQLQ)评分、血清微量元素水平及不良反应情况。[结果]与治疗前相比,两组患者治疗后鼻塞、鼻痒、喷嚏及流涕症状显著改善(P＜0.05),且观察组改善程度显著优于对照组(P＜0.05);与治疗前相比,两组患者治疗后锌含量显著升高(P＜0.05),铜含量和RQLQ评分显著降低(P＜0.05),且观察组锌含量显著高于对照组(P＜0.05),铜含量和RQLQ评分显著低于对照组(P＜0.05);两组患者不良反应发生率比较差异无统计学意义(P＞0.05)。[结论]通窍鼻炎颗粒与抗组胺药联合治疗AR能改善患者临床症状和生活质量,调节血清微量元素水平,且安全性较高。

Abstract:

[Objective] To analyze the effects of Tongqiao Biyan Granule combined with antihistamine in the treatment of allergic rhinitis patients(AR) and its influence on clinical symptoms and quality of life. [Methods] The 126 AR patients admitted to our hospital from April 2019 to May 2021 were selected. They were divided into control group and observation group by random grouping method,63 cases in each group. The control group was treated with aztrostine hydrochloride,the observation group was given Tongqiao Biyan Granule on the basis of control group. Clinical symptoms,naso-conjunctivitis related quality of life questionnaire(RQLQ) score,serum trace element levels and adverse reactions were compared between two groups. [Results] Compared with before treatment,the symptoms of nasal congestion,nasal itching,sneezing and runny nose in 2 groups were significantly improved after treatment(P＜0.05),and the improvement degree of observation group was significantly better than control group(P＜0.05). Compared with before treatment,zinc content in 2 groups was significantly increased(P＜0.05);copper content and RQLQ score were significantly decreased(P＜0.05),and zinc content in observation group was significantly higher than that in control group(P＜0.05);copper content and RQLQ score were significantly lower than that in control group(P＜0.05). There was no significant difference in the incidence of adverse reactions between 2 groups(P＞0.05).[Conclusion] Tongqiao Biyan Granule combined with antihistamine has good efficacy in the treatment of AR patients,which can improve the clinical symptoms and quality of life of patients,and regulate the level of serum trace elements,with high safety.