乳果糖、微生态制剂联合四磨汤对老年糖尿病便秘患者肠动力及血清肠神经递质指标的影响

Effects of lactulose and probiotics combined with Simo Decoction on intestinal motility and serum intestinal neurotransmitters in senile diabetic patients with constipatio

关键词:  乳果糖  微生物制剂  四磨汤  糖尿病  便秘

Key words:  lactulose  microbial preparation  Simo Decoction  diabetes  constipation

摘要:

[目的] 探讨乳果糖、微生态制剂联合四磨汤对老年糖尿病中便秘患者肠动力及血清肠神经递质指标的影响。[方法] 选取2019年6月—2021年6月于驻马店市中心医院收治的102例老年糖尿病合并便秘患者，依据随机数表法将患者分为观察组与对照组，51例对照组患者给予三联疗法（莫沙必利、乳果糖口服液、双歧杆菌），51例观察组患者同时口服四磨汤。对两组的临床疗效和症状改变情况进行比较，并比较血清肠神经递质指[血管活性肠肽（VIP）、生长抑素（SS）、胃动素（MTL）、血清P物质（SP）、一氧化氮（NO）]、胃肠道动力[直肠乙状结肠传输时间（RSTT）、左半结肠传输时间（LCTT）及右半结肠传输时间（RCTT）]等。[结果] 观察组患者临床有效率高于对照组（P＜0.05）。治疗后，与对照组比较，观察组临床症状各项评分及VIP、SS及NO水平均较低（P＜0.05），SP水平较高（P＜0.05）。观察组治疗后患者RSTT、LCTT及RCTT短于对照组（P＜0.05）。[结论] 乳果糖、微生态制剂联合四磨汤有利于缓解老年糖尿病患者便秘症状、改善患者肠动力及血清肠神经递质指标，疗效显著。

Abstract:

[Objective] To investigate the effects of lactudrop,probiotics combined with Simo Decoction on intestinal motility and serum intestinal neurotransmitters in senile diabetes patients with constipation. [Methods] Selection in June 2019 to June 2021 treated in Zhumadian Geriatrics Hospital 102 cases of senile diabetic patients with constipation,based on the stochastic indicator method divided the patients into observation group and control group,51 cases of control group patients give triple therapy (moser will benefit,lactulose oral liquid,bifidobacterium),51 cases on the basis of the observation group of patients in the control group given Simo Decoction for treatment. The clinical efficacy and symptom changes (frequency of spontaneous defecation,abdominal distension,abdominal pain, endless defecation,defecate difficulty scores),serum bowel to neurotransmitter[vasoactive intestinal peptide(VIP) and somatostatin (SS),gastric dynamic element(MTL),serum levels of substance P(SP),nitric oxide(NO)],gastrointestinal dynamics[sigmoid colon rectum transmission time(RSTT),left half colon transmission time(LCTT) and the right half colon transmission time(RCTT)],etc. [Results] The clinical effective rate of observation group was higher than control group(P<0.05). After treatment,the spontaneous defecation rate,abdominal distention,abdominal pain,defecation failure and defecation difficulty score in observation group were lower than those in control group(P<0.05). After treatment,the levels of VIP,SS and NO in observation group were lower than those in control group (P<0.05),and SP level in observation group was higher than that in control group(P<0.05). RSTT,LCTT and RCTT in the observation group were shorter than those in the control group(P<0.05). [Conclusion] Lactulose and probiotics combined with Simo Decoction can relieve constipation symptoms,improve intestinal motility and serum intestinal neurotransmitters in elderly diabetic patients,and have significant efficacy.