桂枝加黄芪汤联合针刺治疗变应性鼻炎肺气虚寒证临床观察

Clinical observation of Guizhi plus Huangqi Decoction combined acupuncture treatment of allergic rhinitis lung qi deficiency cold syndrome

关键词:  桂枝加黄芪汤  针刺  变应性鼻炎  炎症  鼻黏膜纤毛功能

Key words:  Guizhi plus Huangqi Decoction  acupuncture  allergic rhinitis  inflammation  nasal mucociliary function

摘要:

[目的] 观察桂枝加黄芪汤联合针刺治疗变应性鼻炎肺气虚寒证的临床疗效。[方法] 选择变应性鼻炎患者80例，根据随机数字表法随机分为西医组与中医组，每组各40例。西医组给予常规西医治疗，中医组在西医组基础上给予患者桂枝加黄芪汤及针刺治疗，观察两组治疗前后血清水通道蛋白1（AQP1）、特应性免疫球蛋白E（IgE）、核转录因子-κB（NF-κB）、正五聚蛋白3（PTX3）表达水平。检测鼻腔分泌物嗜酸性粒细胞（EOS），给予两组患者过敏性鼻炎症状评分（TNSS+TNNSS）、鼻结膜炎生存质量量表（RQLQ）评价，比较两组临床疗效。[结果] 治疗后，中医组EOS、IgE含量较西医组低，差异有统计学意义（P＜0.05）；中医组AQP1、NF-κB、PTX3含量较西医组明显低，差异有统计学意义（P＜0.05）；中医组鼻黏膜纤毛清除速率较西医组高、鼻阻力较西医组低、鼻黏膜纤毛传输时间较西医组短，差异有统计学意义（P均＜0.05）；中医组过敏性鼻炎症状评分（TNSS+TNNSS）较西医组低，差异有统计学意义（P＜0.05）；中医组患者RQLQ评分低于西医组，差异有统计学意义（P＜0.05）。中医组总有效率为97.50%，西医组为80.00%，两组比较，差异有统计学意义（P＜0.05）。[结论] 桂枝加黄芪汤联合针刺治疗变应性鼻炎肺气虚寒证患者，可降低EOS、IgE水平，抑制机体炎症，改善鼻部通气及鼻黏膜纤毛功能，缓解临床症状，降低RQLQ评分，提升患者临床疗效。

Abstract:

[Objective] To observe the clinical effect of Guizhi plus Huangqi Decoction combined acupuncture on allergic rhinitis syndrome of lung qi deficiency and cold. [Methods] The 80 patients with allergic rhinitis were selected and divided into Western medicine group and Chinese medicine group according to random number table,40 cases in each group. The Western medicine group was given conventional Western medicine treatment,and the Chinese medicine group was given Guizhi plus Huangqi Decoction and acupuncture treatment on the basis of the Western medicine group. The expression levels of serum aquaporin 1 (AQP1),atopic immunoglobulin E(IgE),nuclear transcription factor-κB(NF-κB) and n-pentammer protein 3(PTX3) in the two groups were observed before and after treatment. Eosinophils(EOS) of nasal secretions were detected,and allergic rhinitis symptom score(TNSS+TNNSS) and nasoconjunctivitis Quality of Life Scale(RQLQ) were evaluated between the two groups,and the clinical efficacy was compared between the two groups. [Results] After treatment,the contents of EOS and IgE in Chinese medicine group were lower than those in Western group,and the difference was statistically significant(P<0.05). After treatment,the contents of AQP1,NF-κB and PTX3 in Chinese medicine group were significantly lower than those in Western group,and the difference was statistically significant(P<0.05). After treatment,the clearance rate of nasal mucosa cilia in the Chinese medicine group was higher than that in the Western group,the nasal resistance was lower,and the transmission time of nasal mucosa cilia was shorter than that in the Western group,with statistical significance(P<0.05). After treatment,symptom score of allergic rhinitis(TNSS+TNNSS) in Chinese medicine group was lower than that in Western group,and the difference was statistically significant(P<0.05). After treatment,RQLQ score in Chinese medicine group was lower than that in Western group,and the difference was statistically significant(P<0.05). After treatment,the total effective rate was 97.50% in the Chinese medicine group and 80.00% in the Western medicine group,and the difference was statistically significant(P<0.05). [Conclusion] Guizhi plus Huangqi Decoction combined acupuncture in the treatment of allergic rhinitis patients with lung qi deficiency and cold syndrome can reduce EOS and IgE levels,inhibit body inflammation,improve nasal ventilation and nasal mucociliary function, relieve clinical symptoms,reduce RQLQ score,and improve clinical efficacy of patients.