重楼皂苷抗肿瘤作用研究进展

Research progress on anti-tumor effects of Polyphyllin

关键词:  重楼皂苷  化学  抗肿瘤  毒性及安全性评价  研究进展

Key words:  Polyphyllin  chemistry  anti-tumor  toxicity and safety evaluation  research progress

摘要:

肿瘤极大威胁着人类健康，研究人员一直在探索和研究中药抗肿瘤作用及其抗肿瘤机制。据报道，重楼皂苷具有抗肿瘤活性，通过诱导肿瘤细胞凋亡、调控细胞周期、诱导肿瘤细胞保护性自噬、抑制肿瘤细胞侵袭和转移、逆转耐药性、协同抗肿瘤等途径发挥抗肿瘤作用。通过PubMed、Web of Science、中国知网等数据库梳理近十年重楼皂苷抗肿瘤作用相关及分子机制进行综述，并且对其毒性和安全性进行评价，希望通过这一综述为重楼皂苷多途径多靶点有效成分的开发利用和临床抗肿瘤应用提供进一步理论参考。

Abstract:

Malignant tumors pose a significant threat to human health. Researchers have been extensively investigating the anti-tumor effects and underlying mechanisms of traditional Chinese medicine. Current studies demonstrate that Polyphyllin exhibits potent anti-tumor activities through multiple pathways，including inducing tumor cell apoptosis，regulating cell cycle，triggering protective autophagy in tumor cells，inhibiting tumor cell invasion and metastasis，reversing drug resistance，and producing synergistic anti-tumor effects. This review comprehensively summarizes the anti-tumor mechanisms of Polyphyllin reported in the past decade based on literature from PubMed，Web of Science，and CNKI databases，while also evaluating its toxicity and safety profiles. The findings may provide valuable theoretical references for further development of Polyphyllin as a multi-target anti-tumor agent and its clinical applications in cancer treatment.