衣原体肺炎感染在主动脉粥样硬化形成和发展中的意义

Role of Chlamydia pneumoniae in aortic atherosclerosis development

关键词:  衣原体肺炎  动脉粥样硬化  免疫组化  病理组织学

Key words:  Chlamydia pneumoniae  Atherosclerosis  Immunohistochemistry  Histopathology

摘要:

[目的]从人体病理组织学的角度来探讨衣原体肺炎感染在主动脉粥样硬化形成和发展过程中的意义。[方法]用免疫组化法和PCR法对100例尸检采取的主动脉组织标本(共960份)进行衣原体肺炎特殊性抗原和DNA的检测,并根据美国心脏学会的动脉粥样硬化组织学分类标准对所有标本进行分类。然后对性别对照组,各个年龄组以及4个内膜病变组的衣原体肺炎阳性率进行统计学对照分析。[结果]衣原体肺炎阳性率在100例主动脉中为76%(其中用免疫组化法为53%,用PCR法为42%),各个年龄组以及性别对照组比较结果显示均没有统计学上的差异。在对76阳性例中的760份标本分成的4个内膜病变组进行比较分析时发现,衣原体肺炎阳性率在主动脉粥样硬化的初期病变组有意义呈高值,而随着病变程度的进展,却有意义地显着降低。[结论]衣原体肺炎感染只对主动脉粥样硬化初期病变的形成有一定影响,而在促使动脉粥样硬化发展和晚期病变的形成上没有直接作用。

Abstract:

[Objective] To study the slgnlficance of Chlamydia pneumonlae (C.pneumonlae) during the course offormatlon and development of atherosclerosls from the pathology and hlstology.[Methods] A total of 960 pathologcal samples from 100 autopsled Japanese patlents were examlned by lmmunohlstochemlstry (IHC) and polymerase chaln reactlon (PCR).The detectable frequency of C.pneumonlae as well as atherosclerostlc Intlmal leslon type were observed,and thelr assoclatlon was forther analyzed.[Results] C.pneumonlae was detected In 76 out of 100 cases (by IHC and PCR),53 by IHC and 43 by PCR.There was no significant statistical difference in the detectable frequency of C.pneumoniae between different sex or age.In analyses exclusive for the 76 C.pneumoniae-positive cases,the detectable frequency of C.pneumoniae detection was the highest in the initial lesion and fatty streak lesion,and thereafter decreased with progression of aortic atherosclerosls.[Conclusion] The detectable frequency of C.pneumonlae does not assoclate with Progresslon of intlmal lesion in aorta.The role of C.pneumoniae in aortic atherosclerosis development is confined mostly to the early stage.