X染色体异常对人类卵巢发育及功能影响的研究

Influence of chromosome X abnormity on development and function of human ovary

关键词:  X染色体  卵巢  性激素

Key words:  chromosome X  ovary  sex hormone

摘要:

[目的]探讨X染色体对人类卵巢发育及功能影响的遗传学效应。[方法]对28例X染色体数目或结构异常的原发闭经、继发闭经和不规则闭经患者进行分析,同时进行性激素水平检测。[结果]X染色体数目异常17例;结构畸变11例。45,X0患者,促卵泡激素FSH和黄体生成素LH高于正常值,t值分别为19.565、19.901,P值均为0.000;且高于其他数目异常个体(FSH)、(LH)水平,t值分别为4.531、3.478,P值为0.012、0.013。[结论]X染色体数目异常或结构畸变,是造成卵巢发育和功能障碍的主要因素。

Abstract:

[Objective] To probe into the genetic effect of chromosome X on the development and function of human ovary. [Methods] Twenty-eight patients with primacy or secondary or irregular amenorrhea due to numerical or structural abnormity of chromosome were analyzed. Their sex hormone was detected simultaneously. [Result] Seventeen cases belong to numerical abnormity and 11 cases to structural abnormity. FSH and LH in cases with 4S, XO were higher than in healthy person [t=19.565 (FSH), t=19.091(LH), P=0.000 (FSH,LH)]. They also higher than in other patients with numerical abnormity [t=4.531,P=0.012 (FSH); t=3.478, P=0.013 (LH)]. [Conclusion] Numerical or structural abnormity of chromosome X are the main causes of disturbance of ovary development and function.