调肝导浊中药及抗氧化损伤的实验研究*

Experimental research of Tiaogan Daozhuo Decoction on lipid metabolism and anti-oxidation injury

关键词:  调肝导浊  动脉粥样硬化  超氧化物歧化酶

Key words:  Tiaogan Daozhuo (regulating the liver and removing the turbid)  atherosclerosis (AS)  lipid  liver  malondialdchydc(MDA)  supcroxidc dismutasc (SOD)

摘要:

[目的]探讨调肝导浊中药对实验性动脉粥样硬化(AS)家兔模型肝脏脂质代谢及抗氧化损伤的影响,以阐明其抗动脉粥样硬化的作用机制。[方法]采用高胆固醇饮食饲喂家兔,并在饲喂过程中依分组进行不同处理。实验结束后,处死动物取肝脏,检测肝脏胆固醇(TC)、甘油三酯(TG)及丙二醛(MDA)含量以及超氧化物歧化酶(SOD)的活性变化。[结果]AS模型组家兔肝脏TC、TG、MDA含量明显升高,SOD活性则显著降低;而调肝导浊中药则可有效抑制此作用。[结论]调肝导浊中药可有效抑制高胆固醇饮食诱导的脂质含量升高及氧化损伤,从而阻止AS的发生发展。

Abstract:

[Objective] To investigate the influence of Chinese medicine Tiaogan Daozhuo Decoction on lipid metabolism and anti-oxidation injury in rabbits with Atherosclerosis (AS) and the mechanisms of anti-AS.[Methods] The rabbits were fed with cholesterol-rich diet and underwent different management in each group simultaneously The content of total cholesterol (TC), triglyceride (TG), and malondiaLdchyde(MDA) and the activity of superoxide dismutase (SOD) in the liver were detected at the end of experiment.[Result] The content of TC, TG, MDA in model group was enhanced and the activity of SOD was decreased markedly. Tiaogan Daozhuo Decoction could inhibit the changes effectively.[Conclusion] Tiaogan Daozhuo Decoction can prevent the formation and progress of AS by inhibiting the high content of lipid and oxidation injury induced by cholesterol-rich diet.