| 摘要: |
| [目的]通过观察丹酚酸-B对心肌缺血再灌注损伤大鼠的实验观察探讨其作用机制。[方法]将实验动物分为5组,假手术组、模型组、卡托普利组、复方丹参片组、丹酚酸-B组分别给于不同处理因素。[结果]丹酚酸-B可降低RI大鼠血浆AT-1、ET、TXA2、TNF、Ca2+水平,提高PGI2、SOD水平,明显优于复方丹参片组及模型组(P<0.05)。[结论]丹酚酸-B具有较好的RI心肌细胞保护作用。 |
| 关键词: 心肌损伤 缺血/再灌注 丹酚酸B 大鼠 |
| DOI：10.11656/j.issn.1673-9043.2004.03.10 |
| 分类号: |
| 基金项目:*天津市卫生局科研基金资助课题(97022) |
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| Protectivse Mechanism of Salviol Acid B against Acute Myocardial Ischemia/Reperfusion Injury in Rats |
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WANG Baohe,FU Wei,LI Zhuting
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The Second Hospital Affiliated to Tianjin University of TCM, Tianjin, 300150
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| Abstract: |
| [Objective] The present study was designed to investigate the protective mechanism of Salvoid acid B against acute myocardial injury induced by ischemia/reperfusion in rats.[Methods] Experimental animals were randomized to 5 groups,receiving sham operation,model preparation,Captopril,FufangDanshen Pian (Tablet of complex prescription of Radix Salviae Miltiorrhizae),and Salviol acid B respectively.[Results] Salviol acid B Could decrease the plasma level of AF-1,ET,TXA2 TNF and Ca2+ and increase PGI2 and SOD in rats.Its action was markedly superior to that in FufangDanshen Pian and model group. (P<0.05). [Conclusion] Salviol acid B possesses better protective effect for myocardial cell during ischemia/reperfusion. |
| Key words: myocardial injury ischemia/reperfusion Salviol acid B rat |
