| 摘要: |
| [目的]探讨肺血栓栓塞症(PTE)患者抗凝系统的变化及其对诊断的价值。[方法]选取35例确诊的急性PTE患者和30例正常人为研究对象,分别测定血浆抗凝血酶Ⅲ活性(AT-Ⅲ)、蛋白C(PC)活性、蛋白S(PS)活性。[结果]PTE患者血浆中抗凝血酶Ⅲ活性,蛋白C活性及蛋白S活性均显著低于对照组(P<0.05);这些指标在单纯PTE组和PTE+深静脉血栓形成(DVT)组间无统计学意义;吸烟对其影响不大。[结论]PTE患者存在抗凝系统活性减低;部分患者可能存在抗凝血系统的缺陷;这些指标对于PTE的诊断有一定价值。 |
| 关键词: 肺血栓栓塞症 抗凝系统 抗凝血酶-Ⅲ 蛋白C 蛋白S |
| DOI：10.11656/j.issn.1673-9043.2006.02.08 |
| 分类号: |
| 基金项目:* 天津市卫生局资助项目(03K227) |
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| Changes of Anticoagulation System Changes in Patients with Pulmonary Thromboembolism |
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JIA Wei,WU Qi,LI Yue-chuan
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General Hospital of Tianjin Medical University, Tianjin 300052, China
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| Abstract: |
| [Objective] To investigate the changer of anticoagulation system in patients with pulmonary thromboembolism(PTE) and evaluate its diagnostic value. [Methods] Thirty-five acute PTE and thirty healthy persons(control) were selected and the activity of antithrombin Ⅲ (AT-Ⅲ),protein C (PC) and protein S (PS) was measured respectively. [Result] The activity of AT-Ⅲ,protein C and protein S in patients with PTE was significantly lower than those of the control group (P<0.05). The comparison of these indexes between PTE group and PTE plus deep venous thrombosis (DVT) group hadn't statistical difference and smoking had less influence. [Conclusion] The anticoagulant activity decreuses in patients with PTE and some patients may have the anticoagulant system deficiency. What is more, these figures play an important role in the diagnosis of PTE. |
| Key words: pulmonary thromboembolism anticoagulation system antithrombin protein C protein S |
