活血清解灵对急性胆道感染肺损伤的保护作用*

Protective Effect of Traditional Chinese Herbs Against Damage of Lung in Rats with Acute Cholangitis Infection

关键词:  急性胆道感染  中药  治疗

Key words:  acute cholangitis infection  traditional Chinese herbs  protective effect

摘要:

[目的]观察胆管减压加中药对急性胆道感染肺损伤的保护作用。[方法]制造大鼠急性胆道感染模型,灌胃给中药汤剂后,检测肺毛细血管通透性,肺磷脂酶A₂活性,血气分析和检测血清铁蛋白含量。[结果]急性胆道感染大鼠肺毛细血管通透性增加,肺组织中磷脂酶A₂活性增强,动脉氧分压(PaO₂)下降,动脉二氧化碳分压(PaCO₂)上升,血清铁蛋白浓度升高。胆管减压加中药治疗可明显抑制毛细血管通透性增加,并抑制磷脂酶A₂活性增强,使上升,PaCO₂下降,血清铁蛋白浓度降低。[结论]胆管减压加中药治疗对急性胆道感染肺损伤有保护作用。

Abstract:

[Objective] To observe the protective effects of traditional Chinese herbs combined with bile vessel decompression on lung damage rats with acute cholangitis infection. [Methods] To establish acute cholangitis infection model rats and intragastric administrate to traditional Chinese herbs decoction. To determine lung capillary permeability, phospholipase A₂, blood gas analysis and serum ferritin content. [Results] The damage rats with acute cholangitis infection showed that lung capillary permeability, phospholipase A₂, serum ferritin and PaCO₂ increased, PaO₂ decreased. After treatment lung capillary permeability, phospholipase A₂, serum ferritin and PaCO₂ remarkable decreased, PaO₂ remarkable increased. [Conclusion] Treatment with traditional Chinese herbs combined with bile vessel decompression may protec[the lung function of rats with aoute cholangitis irrfeotion.