护肝汤治疗精神药物所致肝胆湿热型肝损害的临床研究

The Clinical Study of Hugantang in the Treatment of Liver Desease Induced by Drugs

关键词:  护肝汤  抗精神病药物  药物性肝损害

Key words:  hugantang  antipsychotics  Drug-induced liver decease

摘要:

[目的]护肝汤治疗抗精神病药物所致肝损害的疗效探讨。[方法]将55例抗精神病药物所致肝损害患者随机双盲分为两组熏治疗组28例,予护肝汤治疗;对照组27例,予凯西莱治疗。观察临床症状及丙氨酸转移酶(AST)、天冬氨酸转移酶(ALT)的变化4周。[结果]治疗4周后,治疗组临床症状、AST、ALT的改善情况与对照组相当(P>0.05);治疗组显效率及总有效率分别为64.3%和92.9%,对照组显效率及总有效率分别为63.0%与96.3%。[结论]护肝汤对治疗抗精神病药物造成的以转氨酶升高为主的肝损害疗效显著,值得临床推广。

Abstract:

[Objective] To explore the efficacy of Hugantang in treating hepatic damage induced by antipsychotics.[Methods] Fifty-five cases of psychiatric patients with hepatic damage induced by antipsychotics were randomly divided into two grups, the experimental group (n=28), treated by Hugantang. Twenty-seven cases in control group, treated by Tiopronin. After that, some clinic symptom and biochemical indexes reflecting liver function were observed and compared for 4 weeks.[Results] Four-Week treatment later, clinic symptom, AST, ALT as well as their recovery rates in treatment group were equal to those in the control group(P>0.05). The significantly effective rate and the overall effective rate in the treatmentgroup were 64.3%. and 92.9%, respectively, which were 63.0% and 96.3% respectively, in control group.[Conclusions] Hugantang can decrease the level of AST, ALT and has more effective in the treatment of hepatic damage induced by antipsychotics.