益气活血散结法对肺纤维化的干预效果及机制研究

Interference of tonifying qi, activating blood and dispersing accumulation on pulmonary fibrosis and the mechanism research

关键词:  肺纤维化  益气活血散结法  转化生长因子-β1

Key words:  pulmonary fibrosis  the method of tonifying Qi,activating blood and dispersing accumulation  TGF-β1

摘要:

[目的]探讨益气活血散结法对肺纤维化的干预效果及机制。[方法]通过临床与动物实验系统研究益气活血散结法为主要治则的中药复方对肺纤维化的干预效果及机制。[结果]益气活血散结法不仅能明显改善肺纤维化患者的临床症状,提高生活质量,而且能抑制肺泡炎症,减少肺组织损伤,显著降低转化生长因子-β1(TGF-β1)的过度表达。[结论]益气活血散结法能改善肺纤维化患者临床症状,对防治肺纤维化有一定的作用。

Abstract:

[Objective] To explore the intervention effect of tonifying Qi,activating blood and dispersing accumulation method on pulmonary fibrosis and analyze its mechanism.[Methods] A systematic clinical observation and animal experimental study on the effect of tonifying Qi,activating blood and dispersing accumulation on pulmonary fibrosis and their mechanism research were carried out.[Results] The method of tonifying Qi,activating blood and dispersing accumulation could not only improve the patients'symptoms obviously,but also inhibit the inflammation in lung alveoli,reduce TGF-β1 over-expression.[Conclusion]The method of tonifying Qi,activating blood and dispersing accumulation can improve the patients'symptoms,and play an important role in preventing and curing pulmonary fibrosis.