炙甘草汤及其加减方治疗“脉结代、心动悸”临床对照试验的系统评价*

A systematic assessment on the clinical controlled trial in treating pulse-arrhythmia and heart-palpitation with Zhigancaodecoction and Its modified prescription

关键词:  炙甘草汤  脉结代、心动悸  临床对照研究  系统评价

Key words:  Zhigancao decoction  pulse-arrhythmia  heart-palpitation  clinical controlled trial  systematic assessment

摘要:

[目的] 系统评价国内炙甘草汤及其加减方治疗"脉结代、心动悸"的临床对照试验的疗效,为其进一步完善炙甘草汤临床研究设计提供理论依据。[方法] 搜集炙甘草汤及其加减方临床对照研究试验,筛选合格文献,文献质量评价按Cochrane系统评价手册4.2.2版关于随机对照试验(RCT)的质量评价标准进行。[结果] 检索到符合纳入标准的临床对照研究试验37篇。按照Cochrane评价标准,均属于C级。[结论] 从现有研究来看,炙甘草汤及其加减方治疗"脉结代、心动悸"相对对照组而言更有优势。但是可供纳入的文献质量普遍不高,所以有待于进一步研究,希望能多出现大样本高质量的临床随机对照试验。

Abstract:

[Objective] To systematically assess the clinical controlled trial in treating pulse-ar-rhythmia (irregularly intermittent and regularly intermittent) and heart-palpitation (severe palpitation) with Zhigancao decoction and its modified prescription in order to providing a theoretic foundation for further perfecting the designing of clinical investigation of Zhigancao decoction. [Methods] The clinical controlled trials of Zhigancao decoction and its modified prescriptions in treating the pulse-arrhythmia and heart-palpitation were collected and the qualified research in them was selected.Their quality evaluation was performed by using the Cochrane system estimation manual of 4.2.2 edition about RCT.[Results] Thirty clinical controlled trials were found,among them the research finished in a single-center were 30.According to the assessing standard of Cochrane,all articles belonged to scale C.[Conclusion] From these available researches it is considered that the effects of Zhigancao decoction and its modified prescriptions in treating pulse-arrhythmia and heart-palpitate were more superior than that of the control group.But the quality of the literatures was not so high generally.Much more clinically controlled trials with high quality were expected.