| 摘要: |
| [目的] 观察通脉养心丸在整体水平下的抗肾上腺素急性心律失常作用。[方法] 采用舌下静注盐酸肾上腺素复制大鼠急性心律失常模型,观察通脉养心丸对心律失常潜伏期(min)、持续时间(min)、心律失常发生率(%)以及注射肾上腺素后30min后血清超氧化物歧化酶(SOD)活力(kU/L)、丙二醛(MDA)(μmol/L)含量的影响。[结果] 静注肾上腺素可由自律性增高致室性心律失常。通脉养心丸能显著缩短盐酸肾上腺素所致心律失常潜伏期及持续时间,降低心律失常发生率,并能提高血清SOD活力,降低MDA含量。[结论] 通脉养心丸具有抗肾上腺素所致大鼠急性心律失常的作用。 |
| 关键词: 通脉养心丸 肾上腺素 心律失常 |
| DOI：10.11656/j.issn.1673-9043.2009.03.13 |
| 分类号: |
| 基金项目: |
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| Effect of tongmai yangxin pill in treating adrenaline-induced acute arrhythmia |
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CAI Xiao-jun,WANG Yi,HU Li-min
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Department of Pharmacology and Toxicology, Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To observe the anti-arrhythmic action of Tongmai Yangxin Pill in adrenline-induced acute arrhythmia in vivo.[Methods] Based on the model of acute arrhythmia established by sublingual intravenous injection of adrenaline, the therapeutic effect of Tongmai Yangxin Pill in the latency, duration and occurrence of arrhythmia was analyzed. Simultaneously, the activity of super oxide dismutase (SOD) and the content of malondialdehyde in serum were determined 30 minutes after intravenous injection of adrenaline.[Results] Adrenaline induced arrhythmias due to increased automony. The latency and duration as well as the occurrence of adernaline-induced arrhythmia could be significantly reduced by preadministration with Tongmai Yangxin Pill. At the same time, the activity of serum SOD was increased and the content of serum malondialdehyde was decreased.[Conclusion] Tongmai Yangxin Pill has protective effect against adrenaline-induced acute arrhythmia in rats. |
| Key words: Tongmai Yangxin Pill adrenaline arrhythmia |
