| 摘要: |
| [目的]研究葛根素注射液在家兔体内的药动学规律。[方法]家兔耳缘静脉注射葛根素注射液后,采用高效液相色谱法测定血浆中葛根素的含量。[结果]葛根素的血药浓度-时间曲线符合三室开放模型,其主要药动学参数分别为消除相半衰期(t1/2β)=1.33h,血药浓度-时间曲线下面积(AUC)=13.0(mg/L)·h,消除率[CL(S)]=6.16mg/kg/h(/mg·L)。[结论]明确了葛根素在家兔体内的药动学特征。 |
| 关键词: 葛根素 高效液相色谱 药动学 |
| DOI：10.11656/j.issn.1673-9043.2009.04.15 |
| 分类号: |
| 基金项目: |
|
| Study on pharmacokinetics of puerarin injection in rabbits |
|
Mo Fan,Xiao Xue-feng,Qiao Xiao-li
|
|
Tianjin University of TCM, Tianjin 300193, China
|
| Abstract: |
| [Objective] To observe the pharmacokinetic characteristics of Puerarin injection in rabbits. [Methods] After giving of injection of Puerarin i.v.into rabbits,HPLC was used to determine the puerarin levels in the biological samples.[Results] The plasma concentration-time course of puerarin fitted well to one-compartment model and with the following pharmacokinetic parameters:Ke=0.02min-1,t1/2ke=35.66min,AUC=495.27 (mg/kg) omin.[Conclusion] The pharmacokinetic characteristics of puerarin in rabbits was understood. |
| Key words: Puerarin HPLC Pharmacokinetic |
