化浊行血丸治疗颈动脉粥样硬化症的临床研究*

Clinical study on therapeutic effect of huazhuo xingxue pill in carotid artery artherosclerosis

关键词:  清化血浊法  化浊行血丸  动脉粥样硬化  脑梗死  临床研究

Key words:  clear turbid blood  Huazhuo Xingxue pill  artherosclerosis  cerebral infarction  clinical study

摘要:

[目的]观察化浊行血丸对颈动脉粥样硬化症的临床疗效。[方法]将确诊的动脉粥硬化性脑梗死患者70例随机分为化浊行血丸和阿托伐他汀钙两组,分别在常规治疗基础上给予化浊行血丸和阿托伐他汀钙治疗6个月,并观察治疗前后患者血脂、颈动脉内膜中层厚度及斑块面积的变化。[结果]两组患者治疗后的血清总胆固醇、甘油三酯、低密度脂蛋白及颈动脉内膜中层厚度及斑块面积均较治疗前显著降低(P<0.01,P<0.05),化浊行血丸组高密度脂蛋白较治疗前明显升高(P<0.01),且化浊行血丸组未见不良反应。[结论]化浊行血丸具有安全显著的调脂、稳定斑块和抗动脉粥样硬化的作用。

Abstract:

[Objective] To observe the clinical effect of Huazhuo (removing turbid) Xingxue (running blood) pill on the carotid artherosclerosis.[Methods] Seventy cases established with arteriosclerosis of cerebral infarction were randomly assigned to Huazhuo Xingxue pill group (40 cases) and control group (atorvastatin calcium,30 cases).They were given with Huazhuo Xingxue pill and atorvastatin calsium orally respectively for 6 months.Then the changes of blood fat,carotid artery intima-media thickness and plaque areas were observed before and after treatment.[Results] Compared with that before treatment,the total cholesterol,triglyceride,low density lipoprotein,carotid artery intima-media thickness and plaque areas were significantly decreased (P<0.01,P<0.05) in each group,the high density lipoprotein in the Huazhuo Xingxue pill group was obviously increased (P<0.01).There was no adverse effect in the Huazhuo Xingxue pill group.[Conclusion] Huazhuo Xingxue pill may safely and obviously adjust the blood fat,stabilize plaque and block artherosclerosis.