消岩汤对减轻气虚毒瘀型非小细胞肺癌化疗毒副反应时效关系的临床研究*

Research on time-effect relationship of adverse reaction of Xiao Yan Tang in treating patients with non-small cell lung cancer with Qi deficiency and toxic stasis

关键词:  消岩汤  非小细胞肺癌  化疗  给药时间

Key words:  Xiao Yan tang  non-small cell lung cancer  chemotherapy  dosing time

摘要:

[目的]观察消岩汤对减轻气虚毒瘀型非小细胞肺癌化疗毒副反应时效关系的临床疗效。[方法]60例非小细胞肺癌患者随机分为提前7d应用消岩汤加化疗组、提前3d应用消岩汤加化疗组、消岩汤加化疗组、单纯化疗组。比较4组患者骨髓抑制、肝肾功能、消化道等毒副反应及生活质量之间的差异。[结果]与单纯化疗比较,消岩汤配合化疗使用对改善白细胞毒性、消化道恶心呕吐症状、提高患者生活质量方面疗效显著,其中于化疗前7d应用消岩汤效果最佳。而对于中性粒细胞(NE)、血红蛋白(HGB)及血小板计数(PLT)降低,口腔炎、腹泻及便秘症状,肝脏毒性,泌尿系统毒性方面无显著疗效。[结论]消岩汤在减轻气虚毒瘀型非小细胞肺癌化疗毒副反应方面具有良好效果。

Abstract:

[Objective] To observe the clinical therapeutic effect of the time-effect relationship of Xiao Yan Tang in treating patients with non-small cell lung cancer with Qi deficiency and blood stasis.[Methods] 60 patients with non-small cell lung cancer were randomly divided into a chemotherapy group with 7 days ahead of giving,group with 3 days ahead of using of Xiao Yan Tang combined with chemotherapy,chemotherapy group combined with Xiao Yan Tang and group with chemotherapy only.The myelosuppression,liver and kidney function,adverse effect on gastrointestinal tract and the quality of life were compared between these four groups.[Results] Compared with the group of chemotherapy only,Xiao Yan Tang could significantly improve the toxicity on white blood cell,ameliorate the gastrointestinal symptoms of nausea and vomiting,increase the quality of life of patients.The best therapy could be seen at 7 days ahead of using of Xiao Yan Tang.There was no,however,significant effect on decreasing of NE,HGB and PLT,stomatitis,symptoms of diarrhea and constipation,liver toxicity,urinary system toxicity.[Conclusion] Xiao Yan Tang has good effect on relieving the chemotherapy side effects in patients with non-small cell lung cancer with Q deficiency and blood.