| 摘要: |
| [目的]对香加皮抗心力衰竭有效部位的制备工艺进行研究。[方法]采用制备性快速柱结合精制柱的分步富集法制备香加皮有效部位,分别考察了制备性快速柱的洗脱溶剂、硅胶用量和精制柱的径高比。[结果]确定的制备工艺使有效部位中杠柳毒苷的含量达到50%以上。[结论]确定的香加皮抗心力衰竭有效部位制备工艺稳定、经济、重复性好。 |
| 关键词: 香加皮 有效部位 杠柳毒苷 |
| DOI：10.11656/j.issn.1673-9043.2011.03.16 |
| 分类号: |
| 基金项目:* 国家科技支撑计划“重大新药创制”重大专项(2009ZX09103-372) |
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| Study on preparation technology of effective fraction for anti-heart failure in Cortex Periplocae(Xiangjiapi) |
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YANG Hong1, LIU Hong2,3, REN Xiao-liang2,3, WANG Men2,3, ZHU Xiao-yue2,3
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1.Tianjin University of TCM, Tianjin 300193, China;2.Research Institute of Tianjin University of TCM;3.Key Laboratory of Pharmacology of TCM Formulae, Ministry of Education, Tianjin 300193, China
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| Abstract: |
| [Objective] To study the preparation technology of effective fraction for anti-heart failure in Cortex Periplocae(Xiangjiapi).[Methods] The effective fraction was prepared by the combination of fast-preparation column and refining column.The ratio of raw material to silica gel and ratio of diameter to height were investigated.[Results] By the determined technology,the contents of periplocin in effective fractions were above 50%.[Conclusion] The preparation technology of the effective fraction for anti-heart failure in Cortex Periplocae is stable,economic and reproducible. |
| Key words: Cortex Periplocae effective fraction periplocin |
