黄体退化期用药治疗原发性痛经的临床疗效观察*

Clinical observation on therapeutic effect of administration of drug in treating primary dysmenorrhea during luteal regression stage

关键词:  原发性痛经  经前三剂止痛方  临床疗效

Key words:  primary dysmenorrhea  Jingqian Sanji Zhitong Fang(JQF)  clinical effects

摘要:

[目的]探讨经前三剂止痛方(JQF)不同服药时间对原发性痛经临床疗效的影响。[方法]选取2009年12月—2011年6月间在天津中医药大学附属保康医院及天津市妇产科医院门诊治疗的原发性痛经患者48例,随机分为黄体退化期给药组(A组)、黄体退化期加黄体成熟期给药组(B组)和月经周期给药组(C组),观察评定3组治疗效果。[结果]3组治疗后痛经症状积分均明显降低(P<0.01),A组、B组、C组治疗总有效率分别为93.75%、93.75%和100%,差异无统计学意义(P>0.05);A组、B组、C组治疗前差异无统计学意义(P>0.05)。停药随访3个月经周期,A组疗效明显优于C组(P<0.05)。A组与B组比较差异无统计学意义,痛经程度积分显示疗效有降低的趋势。治疗过程中2组均未见不良反应。[结论]黄体退化期给药治疗原发性痛经用药时间短,与长期用药比,治疗过程中等效,但远期疗效好,治愈率高,值得临床应用。

Abstract:

[Objective] To explore the effect of taking time of Jingqian Sanji Zhitong Fang(JQF) and clinical curative effects of JQF for treating primary dysmenorrhea.[Methods] The 48 patients with primary dysmenorrhea treated in Affiliated Baokang Hospital of Tianjin University of TCM and Tianjin Central Hospital of Gynecology and Obstetrics were selected during December, 2009 to June, 2011. Every one took a dose of medicine per day. The patients were divided randomly into groups of administration in luteal regression stage (group A), administration in luteal regression stage and mature stage (group B) and during the menstrual cycle (group C). The therapeutic effects were observed and evaluated.[Results] The symptoms were significantly relieved after treating. For patients with mild symptoms, the total effective rate was 93.75%, 93.75% and 100% for group A, B and C respectively with no significant difference between them (P>0.05). Compared with the effect before treatment there was no significant difference among these three groups (P>0.05). During the subsequent three months without medication in three menstrual cycles, the curative effects of group A were significantly better than group C (P<0.05). And there was no significant difference between group A and group B. The result proved that curative effect had reduced tendency. No adverse reaction was observed during the therapeutic process.[Conclusion] Administration of drug in luteal regression stage for treating dysmenorrhea takes less time and compared with long term use of JQF, it has the same curative effects. But the therapeutic effect with long term administration has good curative effect, which is worthy of clinical application.