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| 聚乙二醇硬脂酸酯15对黄芩苷角膜透过性研究 |
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张锐1,2, 赵海南1,2, 瞿继兰1,2, 李琳1,2, 李楠1,2, 刘志东1,2
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1.300193 天津中医药大学,天津市现代中药重点实验室-省部共建国家重点实验室培育基地;2.现代中药发现与制剂技术教育部工程研究中心
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| 摘要: |
| [目的] 研究聚乙二醇硬脂酸酯15(Sol)对黄芩苷离体角膜透过率的影响,探讨其在眼用制剂中的应用。[方法]采用离体角膜渗透技术考察不同质量浓度的Sol对黄芩苷角膜透过率的影响。[结果] 0.4%和0.8%的Sol使黄芩苷的表观渗透系数分别增加了2.05倍和1.65倍,与对照组相比差异有统计学意义(P<0.05),而0.2%、1.0%和2.0%的Sol未能显着增大黄芩苷的表观渗透系数(P>0.05).[结论] 0.4%和0.8%的Sol能够显着增大Sol的表观渗透系数,且对角膜无刺激性。 |
| 关键词: 聚乙二醇硬脂酸酯15 角膜透过性 黄芩苷 |
| DOI：10.11656/j.issn.1673-9043.2013.01.10 |
| 分类号: |
| 基金项目:国家自然科学基金项目(81001645);中国博士后科学基金项目(20090460701). |
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| Investigation on corneal permeability for Baicalin of SolutolHS 15 in vitro |
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ZHANG Rui,ZHAO Hai-nan,QU Ji-lan,LI Lin,LI Nan,LIU Zhi-dong
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Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China
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| Abstract: |
| [Objective] To investigate the effect of SolutolHS 15 (Sol) on corneal preparation rate and to explore their use in ophthalmology. [Methods] The effects of Sol on the corneal permeability for Baicalin were investigated in vitro with isolated corneas of rabbit. [Results] The 0.4% and 0.8% Sol could increase the appeared permeability for Baicalin as much as 2.05 and 1.65 times respectively when compared with the permeability in control(P<0.05). However, 0.2%, 1.0% and 2.0% Sol could not improve the appeared permeability for Baicalin(P>0.05). [Conclusion] The 0.4% and 0.8% Sol can enhance the corneal appeared permeability for Baicalin significantly and have not irritation on eye tissues. |
| Key words: SolutolHS 15 corneal permeability Baicalin |
