中药复方治疗慢性肺源性心脏病患者生存质量的调查

Survey of life quality of patients with chronic pneumogenic heart disease treating with compound prescription of TCM

关键词:  肺源性心脏病  6分钟步行试验  生活质量  益气活血化痰

Key words:  CPHD  six-minutes walking test  quality of life  benefiting Qi  activating blood circulation and reducing phlegm

摘要:

[目的] 通过观察中药复方治疗慢性肺源性心脏病气虚血瘀兼痰阻患者生存质量的影响,探讨中西医结合联合干预治疗对患者生存质量的优势和特色。[方法] 共纳入慢性肺源性心脏病气虚血瘀兼痰阻240例患者,分为对照组、治疗组各120例,常规治疗包括给予吸氧、抗感染等,对照组予常规治疗基础上加硝苯地平口服,治疗组予常规治疗加中药复方,疗程2周。记录治疗前后两组的肺功能指标、生活质量评分、6分钟步行距离等,及治疗期间不良反应。[结果] 1)两组治疗前后肺功能的参数、圣乔治呼吸调查问卷的评分结果、6分钟步行距离,差异有统计学意义(P<0.05).2)治疗后:治疗组与对照组肺功能的参数、圣乔治呼吸调查问卷的评分结果、6分钟步行距离差异有统计学意义(P<0.05).说明在改善肺功能、生活质量、6分钟步行距离等方面治疗组优于对照组。3)圣乔治呼吸问卷(SGRQ)3个部分(症状、疾病影响、活动)、总分与用力呼气1秒时间的肺活量(FEV1)占预计值存在负相关关系,其中活动部分与FEV1占预计值相关性最好(相关系数=-0.742).[结论] 中药复方对于慢性肺源性心脏病气虚血瘀兼痰阻患者可以改善其生理的、物理的及社会的参数,改善其肺功能、6分钟步行距离,并可提高其生活质量。

Abstract:

[Objective] To discuss the effect of Chinese compound prescription on the life quality of patients with chronic pneumogenic heart disease(CPHD) in type of Qi deficiency, blood stasis and phlegm stagnation, and explore the advantages and characteristics of intervention with the integrated Chinese and Western medicine in improving the quality of life. [Methods] Two hundred and forty diagnosed CPHD patients were enrolled randomly into this study. They were divided into treatment group(120 cases) and control group(120 cases). Control group were received Nifedipine orally based on the routine treatment, including oxygen inhalation and anti-infective treatment; while treatment group were received Chinese herbal compound prescription by oral way once a day based on the treatment as did in control group. One course of treatment was two weeks. The pulmonary function index, the quality of life score, six minutes walking distance of the two groups before and after treatment and the adverse reaction during treatment were recorded. [Results] 1)Compared with before treatment, the pulmonary function index, Saint George's respiratory questionnaire(SGRQ) results, six minutes walking distance were statistically significant(P<0.05) in both groups. 2)Compared with control group, the lung function index, SGRQ and the six minutes walking distance were statistically different(P<0.05) after treatment, showing an advantage of treatment group in improving lung function, quality of life; 6 minutes walking distance and so on. 3)There was a negative correlation between the three parts of SGRQ (symptoms, disease influence, excise), total score and FEV1 of expected value(the relevant coefficient-0.742). [Conclusion] Chinese herbal compound prescription can improve physiological, physical and social parameters,improve the function of lung, the distance of walking in six minutes and the quality of life in CPHD patients with Qi deficiency and blood stasis combined with phlegm stagnation.