参附注射液治疗慢性心力衰竭临床应用剂量文献调查分析

Literature analysis on dose of Shenfu injection in treating chronic heart failure

关键词:  参附注射液  慢性心力衰竭  剂量  溶媒

Key words:  Shenfu injection  chronic heart failure  dose  solvent

摘要:

[目的] 了解参附注射液治疗慢性心力衰竭的剂量、溶媒及溶媒剂量情况。[方法] 检索中国期刊全文数据库(CNKI),1993年1月-2012年5月文献,查找参附注射液静脉滴注治疗慢性心力衰竭的临床研究。[结果] 参附注射液静脉滴注治疗慢性心力衰竭的剂量以40~60 mL应用广泛(80.01%),其中以50 mL应用最多(35.56%),且安全性好;溶媒采用5%葡萄糖注射液居多(81.11%),大多采用剂量250 mL(55.56%);对于合并糖尿病患者,溶媒采用5%葡萄糖注射液或0.9%的生理盐水,多加入胰岛素治疗(50%).[结论] 临床应用参附注射液治疗慢性心力衰竭大多按照说明书,但应加强参附注射液基础和临床的量效关系研究,探索安全、有效的最佳剂量。

Abstract:

[Objective] To investigate the dose, solvent and solvent-dose of Shenfu injection in treating chronic heart failure. [Methods] The China Full-text Journal Database (CNKI), Jan,1993 to May,2012 was searched, and the clinical studies of Shenfu injection used intravenously for patients with chronic heart failure were found. [Results] The widely used dose of Shenfu injection intravenous infusion in chronic heart failure treatment was within 40~60 mL(80.01%), among them, 50 mL was the most widely applied(35.56%) with better security; 5% dextrose injection as solvent was commonly used(81.11%) and the mostly used dose was 250 mL(55.56%); for patients with diabetes, it was tended to and used 5% dextrose injection or 0.9% saline as solvent add insulin to solvent(50%). [Conclusion] Shenfu injection in therapy for patients with chronic heart failure are mostly applied as drug instruction. However, the research in basic and clinical dose-effect relationship should be strengthened. The optimal safe and effective dose should be explored.