正容凝胶剂研制及临床观察

The preparation and clinical observation of Zhengrong gel

关键词:  正容凝胶剂  剂型改革  面瘫

Key words:  Zhengrong gel  the reform of formulation  facial paralysis

摘要:

[目的] 将传统软膏剂（正容面瘫膏）改制为凝胶剂，并比较两者治疗效果，为周围性面瘫的治疗提供一种更方便、有效的新剂型。[方法] 以卡波姆P940为凝胶基质，制备了正容凝胶剂。将72例门诊面瘫患者按随机数字表法随机分为两组，对照组和治疗组各36例，在西药治疗的基础上，对照组给予正容面瘫膏贴敷，治疗组给予正容凝胶剂贴敷，以治愈率及1个疗程内的痊愈率为指标，比较两组的治疗效果。[结果] 凝胶剂质量良好，与对照组相比，治愈率显着提高，疗程明显缩短，差异均有统计学意义（P<0.05）.[结论] 正容凝胶剂治疗面瘫效果优于传统剂型，使用方便，可作为外用治疗面瘫的新剂型。

Abstract:

[Objective] The traditional ointment (Zhengrong Facial Paralysis Ointment) was changed into gel, and compared their efficacy, to provide a convenient and effective new formulation for the treatment of peripheral facial paralysis. [Methods] The Zhengrong gel was prepared with cabomer P940 as veihele. 72 cases clinic patients with facial paralysis were randomly divided into two groups: the control group (36 cases) and the treatment group (36 cases). On the basis of the treatment of western medicine, the control group were sticked with Zhengrong Facial Paralysis Ointment, the treatment of group were sticked with Zhengrong gel. To compare the treatment effect of the two groups, With the cure rate and the cure rate in a course of treatment ane indexes. [Results] The quality of gel is up to standard. Compared with the control group, the cure rate was increased significantly, and the course of treatment was shortened significantly. the differences between two groups showed statistical significance (P<0.05). [Conclusion] Zhengrong gel had better treatment than The traditional ointment, it is easy to use and can be used as a new formulation for the treatment of peripheral facial paralysis.