| 摘要: |
| [目的] 对国槐（Sophora japonica L.）米中的酚酸类成分进行研究，为进一步开发利用该植物资源提供依据. [方法] 采用正相硅胶、反相ODS、Sephadex LH-20等柱色谱及高效液相色谱法等方法进行分离纯化，并通过理化性质及光谱分析鉴定化合物的结构. [结果] 从国槐米70%的乙醇提取物中分离鉴定了5个酚酸类化合物，分别为3，4-二羟基苯甲酸（1）、原儿茶酸甲酯（2）、没食子酸（3）、4-甲氧基-3，5-羟基苯甲酸（4）、枸橼苦素（5）.[结论] 2、3、5为从槐属中首次分离得到的化合物. |
| 关键词: 槐米 酚酸类成分 结构鉴定 |
| DOI：10.11656/j.issn.1673-9043.2014.01.13 |
| 分类号: |
| 基金项目:国家自然基金项目（81202995）；国家科技重大专项项目-重大新药创制（2011ZX09307-002-01）；新世纪优秀人才支持计划资助项目（NCET-12-1069）. |
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| Study on phenolic acids from Flos Sophorae |
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LIU Li-li, LI Xiao-xia, CHEN Yue, SUN Jin, LIU Er-wei, ZHANG Yi
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Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China
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| Abstract: |
| [Objective] To investigate the phenoic acids of Flos Sophorae for further research and development. [Methods] The chemical components were obtained by using chromatographies such as silica gel, ODS, Sephadex LH-20 and HPLC, and identified by the chemical and physical methods, especially spectral analysis. [Results] Five phenoic acids were obtained and identified as 3,4-dihydroxybenzoic acid(1), protocatechuic acid methyl ester (2), gallic acid (3), 4-methoxy-3,5-dihydroxybenzoic acid (4), and citrusin C (5), respectively. [Conclusion] Compounds 2, 3, and 5 are obtained from sophora genus firstly. |
| Key words: Flos Sophorae phenolic acid structural elucidation |
