| 摘要: |
| [目的] 为了研究中药川续断干燥根的化学成分。[方法] 应用多种色谱手段，对川续断根50%乙醇大孔树脂洗脱部分进行系统的分离和纯化，并利用NMR和MS等方法解析化合物结构。[结果] 共得到6个化合物，分别鉴定为：1）（+）-1-羟基松脂醇4'-O-β-D-吡喃葡萄糖苷。2）3,5-二咖啡酰奎宁酸甲酯。3）4,5-二咖啡酰奎宁酸甲酯。4）5-咖啡酰奎宁酸甲酯。5）马钱子苷。6）demethylsecologanol。[结论] 其中化合物1、4为首次从川续断根中分离得到。 |
| 关键词: 川续断 化学成分 结构鉴定 |
| DOI：10.11656/j.issn.1673-9043.2014.02.14 |
| 分类号: |
| 基金项目:国家科技重大专项（2013ZX09401-004-002）；国家科技重大专项（2012ZX09304007）；天津市高教科技发展基金一般资助项目（20090209）。 |
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| Chemical constituents of Dipsacus asper Ⅲ |
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WANG Qiang, ZHANG Yi, HAN Li-feng, LIU Er-wei
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Key Laboratory of TCM Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China
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| Abstract: |
| [Objective] To study the chemical constituents of Dipsacus asper. [Methods] The compounds were isolated from the 50% ethanol fraction using Macroporous resin by many kinds of chromatography methods and identified on the basis of phytochemical characters and spectroscopic analysis. [Results] Six compounds were obtained and their structures were identified as(+)-1-Hydroxy Pinoresinol 4'-O-β-D-Glucopyranoside(1),methyl 3,5-di-O-caffeoylquinic acid methyl ester(2),methyl 4, 5-di-O-caffeoylquinic acid methyl ester(3), methyl 5-O-caffeoylquinic acid methyl ester(4),loganin(5),demethylsecologanol (6),respectively.[Conclusion] Compounds 1, 4 is isolated from this plant for the first time. |
| Key words: Dipsacus asper chemical composition structure identification |
