不同配比杜仲丸对SAMP6小鼠抗抑郁作用的研究

Study on the antidepressant effect of Duzhongwan with different proportions

关键词:  杜仲丸  抑郁症  强迫游泳实验  悬尾实验  SAMP6小鼠

Key words:  Duzhongwan  depression  forced swimming test  tail suspension test  SAMP6 mice

摘要:

[目的] 研究不同配比杜仲丸的抗抑郁作用.[方法] 采用3月龄快速老化SAMP6小鼠及其同源正常对照SAMR1为研究对象,应用杜仲丸、杜仲和续断进行治疗12周.末次灌胃给药1 h后,采用小鼠旷场实验(OFT)、小鼠悬尾实验(TST)、小鼠强迫游泳实验(FST)研究不同配比的杜仲丸的抗抑郁作用.[结果] 在FST和TST中,杜仲丸低剂量组能显着降低小鼠不动时间(P<0.05或P<0.01).[结论] 杜仲丸具有一定的抗抑郁作用.

Abstract:

[Objective] To study the antidepressant effect of Duzhongwan with different proportions. [Methods] Three months old SAMP6 mice and their normal control mice SAMR1 were enrolled in this study. The SAMP6 mice were treated with high and low dose of Duzhongwan, respectively, contrasting with Duzhong and Xuduan during 12 weeks. At 1h after the administration(ig), the open field test (OFT), the tail suspension test (TST) and the forced swimming test (FST) were used to observe the antidepressant effect of Duzhongwan with different proportions. [Results] The immobility time of SAMP6 mice in Duzhongwan low dose group could significantly reduce in FST and TST,compared with those in the control group(P<0.05 or P<0.01). [Conclusion] The results suggested that Duzhongwan performed antidepressant effect.