| 摘要: |
| [目的] 观察益肺健脾法配合三伏贴敷治疗常年性变应性鼻炎(PAR)的临床疗效以及对血清白介素-4(IL-4)的影响。[方法] 将60例PAR患者按随机数字表法随机分为2组。治疗组30例, 采用益肺健脾法配合三伏贴敷治疗;对照组30例, 口服西替利嗪。观察治疗前、治疗后及治疗结束后3个月外周血IL-4含量变化, 并观察临床症状、体征及临床疗效, 用统计学分析两组间各项指标的差异。[结果] 治疗组和对照组治疗后体征评分比较差异无统计学意义(P>0.05), IL-4水平比较差异无统计学意义(P>0.05), 但症状评分及临床疗效组间比较差异有统计学意义(P<0.01).治疗结束后3个月两组体征评分比较差异无统计学意义(P>0.05), 但症状评分、临床疗效和IL-4水平均差异有统计学意义(P<0.01).[结论] 益肺健脾法配合三伏贴敷能有效治疗PAR, 与其降低血清IL-4水平有关, 提示其能调节患者外周血Th1/Th2细胞因子的失衡状态, 对PAR患者的免疫状态有恢复作用且时间长久。 |
| 关键词: 变应性鼻炎 益肺健脾法 三伏贴敷 白介素-4 |
| DOI：10.11656/j.issn.1673-9043.2015.02.04 |
| 分类号: |
| 基金项目:福建省卫生厅青年课题项目(2013-2-61). |
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| Clinical study on treatment of perennial allergic rhinitis of with the combination of Yifei Jianpi method and dog-day acupoint application |
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YANG Mei-feng1, ZENG Yi-sheng2, LAI Chang-sha3
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1.Fujian University of Traditional Chinese Medicine, Fuzhou 350122;2.E. N. T. department, Second People's Hospital of Fujian Province, Fuzhou 350003;3.Fujian province people's Hospital of Traditional Department of Internal Medicine, Fuzhou 350004
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| Abstract: |
| [Objective] To observe the therapy effect with the combination of Yifei Jianpi Method and dog-day acupoint application of perennial allergic rhinitis(PAR),and the changes of serum interleukin-4(IL-4). [Methods] Sixty patients with perennial allergic rhinitis are randomly divided into two groups with 30 patients eath.The treatment group was treated with the combination of Yifei Jianpi Method and dog-day acupoint application,while control group was treated with cetirizine tables only. Serum level of IL-4 were measured before treatment,at the final treatment and 3 months after treatment.Clinical syndromes and physical signs were observed.[Results] Grade of physical signs and serum lever of IL-4 weren't different after the final treatment between the treatment group and the control group(P>0.05). Grade of clinical symptoms and therapy effect were different after the final treatment between the treatment group and the control group(P<0.01). Grade of physical signs weren't different 3 months after treatment between the treatment group and the control group(P>0.05).Grade of clinical symptoms and therapy effect and serum lever of IL-4 were different after 3 months treatment between the treatment group and the control group(P<0.01).[Conclusion] The combination of Yifei Jianpi method and dog-day acupoint application had extract curative effect in PAR,it was related with which can reduce serum level of IL-4. It can adjust the imbalance of Th1/Th2 and further improve immune state for long time in PAR patients. |
| Key words: allergic rhinitis Yifei Jianpi method dog-day acupoint application IL-4 |
