补肾活血方对肝肾阴虚型红斑狼疮肾炎患者疗效及免疫功能影响

Effects of Bushen Huoxue decoction on immunological condition in patients with lupus nephritis of liver-kidney Yin deficiency syndrome

关键词:  补肾活血方  狼疮肾炎  肝肾阴虚  免疫学

Key words:  Bushen Huoxue decoction  lupus nephritis  liver-kidney Yin deficiency  immunology

摘要:

[目的] 探讨补肾活血方对肝肾阴虚型狼疮肾炎(LN)患者治疗效果及免疫功能影响。[方法] 36例肝肾阴虚型LN患者按随机数字表法分为基础治疗组及联合治疗组,两组均应用甲基泼尼松与环磷酰胺(CTX)冲击治疗,联合治疗组同时应用补肾活血方治疗,4个月后观察两组患者系统性红斑狼疮(SLE)疾病活动指数(SLEDAI)、补体C3、C4、24 h尿蛋白定量、内生肌酐清除率(Ccr)、 血尿素氮(BUN)、CD3⁺、CD4⁺、CD8⁺ 水平。[结果] 联合治疗组患者的SLEDAI、24 h尿蛋白定量、尿素氮、日糖皮质激素用量均明显下降,CD8⁺ 水平下调,与基础治疗组比较有统计学差异(P<0.05).[结论] 补肾活血方能够显着改善肝肾阴虚型狼疮肾炎(LN)患者临床症状,减少糖皮质激素维持应用量,并可在一定程度上纠正免疫功能紊乱。

Abstract:

[Objective] To observe the clinical curative efects of Bushen Huoxue decoction on immunological condition in patients with lupus nephritis(LN)of Liver-kidney Yin deficiency. [Methods] Thirty-six LN patients were randomly divided into foundation treatment group(n=18) and combined treatment group(n=18); steroids and cyclophosphamide(CTX) were administered to all patients,while Bushen Huoxue decoction were only administered to patients in the mixed treatment group.After 3-month treatment,SLE disease activity index score(SLEDAI Score),C3, C4, 24 h urine protein quantity,endogenous creatinine clearance rate(Ccr), blood urea nitrogen(BUN), T lymphocytes subsets(CD3⁺、CD4⁺、CD8⁺), daily dosage of steroids and ill-effects were detected in both groups.[Results] Compared with foundation treatment group, combined treatment group could significantly decrease SLEDAI score,24 h urine protein,urea nitrogen, daily dosage of steroids and ill-effects and down-regulate the level of CD8⁺ T cell(P<0.05). [Conclusion] Bushen Huoxue decoction can significantly ameliorate LN of liver-kidney Yin deficiency syndrome and reduce the dosage of steroids by correcting immune dysfunction.